Fig. 3

a Normal rat and diabetic rat treated with blank, VCN-2 and allantoin dressing on day 7 and 14. Diabetic rats treated with VCN-2 showed more neovascularization on day 14 compared to day 7. Wound of rat on day 14 contained more blood vessels and showed well connective tissue deposition, n = 6, 400x with H&E staining. Abbreviations: (I): Inflammatory cell and (C): Connective tissue. Representation: angiogenesis and : fibroblast cell. b Histological finding score of fibroblast proliferation; (c) angiogenesis and (d) inflammatory cells infiltrate (score from 0 to 4) from 10 randomly chosen high-power fields (× 400) from three sections in wound treated with difference films on day 7 and 14. Data are means ± SEM histological score (n = 6). ###p < 0.001, diabetes versus normal; *p < 0.05, **p < 0.01 and ***p < 0.001, treatment groups versus diabetic