Fig. 2

a Images of healed wound site from a normal rat and diabetic rat with blank, VCN-2 and allantoin dressing treatment on day 7 and 14. Normal rat demonstrating complete re-epithelialization and well-form granulation tissue. Diabetic rat treated with VCN-2 12.5, 25 and 50 μM film consequence re-epithelialization and well-formed granulation tissues on day 7 and 14, (100x with H&E stain). Abbreviation (br): boundary between unhealed and healed tissue; (bv): blood vessels; (h): healed area with multiple layers of fibrous connective tissue; (e): epithelium; ie): immature epidermis; (ig): immature granulation tissue and (u): ulcer. b Histologic scoring for epidermal regeneration. c Histologic scoring for granulation tissues thickness of the rats on day 7 and 14 from 10 randomly chosen fields. Data expressed as means ± SEM (n = 6). ### p < 0.001 is diabetic group compared with normal group; *** p < 0.001 is treated group compared with diabetic group on the same day