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Table 2 List of differentially expressed proteins in vehicle- and γT3-treated senescent cells

From: Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol

Protein ID Protein name (symbol)
Upregulated
 O00487 26S proteasome non-ATPase regulatory subunit 14 (PSMD14)
 P08865 40S ribosomal protein SA (RPSA)
 Q969Q0 60S ribosomal protein L36a-like (RPL36AL)
 P30533 Alpha-2-macroglobulin receptor-associated protein (LRPAP1)
 P40222 Alpha-taxilin (TXLNA)
 P07355;A6NMY6 Annexin A2 (ANXA2);
Putative annexin A2-like protein (ANXA2P2)
 P08758 Annexin A5 (ANXA5)
 Q9NUU7;Q9UMR2 ATP-dependent RNA helicase DDX19A (DDX19A);
ATP-dependent RNA helicase DDX19B (DDX19B)
 Q05682 Caldesmon (CALD1)
 P17612;P22694 cAMP-dependent protein kinase catalytic subunit alpha (PRKACA);
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
 P17812 CTP synthase 1 (CTPS1)
 P54886 Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)
 Q9NZN3 EH domain-containing protein 3 (EHD3)
 O94905 Erlin-2 (ERLIN2)
 O75822 Eukaryotic translation initiation factor 3 subunit J (EIF3J)
 Q9Y262 Eukaryotic translation initiation factor 3 subunit L (EIF3L)
 P14324 Farnesyl pyrophosphate synthase (FDPS)
 P14314 Glucosidase 2 subunit beta (PRKCSH)
 Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1)
 Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase (GRHPR)
 P0DMV9;P0DMV8 Heat shock 70 kDa protein 1B (HSPA71B);
Heat shock 70 kDa protein 1A (HSPA71A)
 Q14103 Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)
 O14979 Heterogeneous nuclear ribonucleoprotein D-like (HNRNDL)
 P31942 Heterogeneous nuclear ribonucleoprotein H3 (HNRNH3)
 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 Q16850 Lanosterol 14-alpha demethylase (CYP51A1)
 Q96AG4 Leucine-rich repeat-containing protein 59 (LRRC59)
 P40926 Malate dehydrogenase, mitochondrial (MDH2)
 P29966 Myristoylated alanine-rich C-kinase substrate (MARCKS)
 Q96AY3 Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)
 P48739 Phosphatidylinositol transfer protein beta isoform (PITPNB)
 O60568 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3)
 Q99623 Prohibitin-2 (PHB2)
 Q86UE4 Protein LYRIC (MTDH)
 Q96M27 Protein PRRC1 (PRRC1)
 Q15436 Protein transport protein Sec23A (SEC23A)
 P35241 Radixin (RDX)
 Q9UN86 Ras GTPase-activating protein-binding protein 2 (G3BP2)
 Q15019 Septin-2 (SEPT2)
 P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)
 Q9BWM7 Sideroflexin-3 (SFXN3)
 P08240 Signal recognition particle receptor subunit alpha (SRPRA)
 O43765 Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA)
 Q9Y5X3 Sorting nexin-5 (SNX5)
 Q8WZ42 Titin (TTN)
 P60174 Triosephosphate isomerase (TPI1)
 P09493 Tropomyosin alpha-1 chain (TPM1)
 P06753 Tropomyosin alpha-3 chain (TPM3)
 Q96FW1 Ubiquitin thioesterase (OTUB1)
Downregulated
 Q15435 Protein phosphatase 1 regulatory subunit 7 (PPP1R7)
 Q59GN2;P62891 Putative 60S ribosomal protein L39-like 5 (RPL39P5);
60S ribosomal protein L39 (RPL39)
  1. Vehicle-treated senescent cells were used as a control group. Proteins were sorted according to alphabetical order