TY - JOUR AU - Tan, Jen-Kit AU - Jaafar, Faizul AU - Makpol, Suzana PY - 2018 DA - 2018/11/29 TI - Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol JO - BMC Complementary and Alternative Medicine SP - 314 VL - 18 IS - 1 AB - Replicative senescence of human diploid fibroblasts (HDFs) has been used as a model to study mechanisms of cellular aging. Gamma-tocotrienol (γT3) is one of the members of vitamin E family which has been shown to increase proliferation of senescent HDFs. However, the modulation of protein expressions by γT3 in senescent HDFs remains to be elucidated. Therefore, this study aimed to determine the differentially expressed proteins (DEPs) in young and senescent HDFs; and in vehicle- and γT3-treated senescent HDFs using label-free quantitative proteomics. SN - 1472-6882 UR - https://doi.org/10.1186/s12906-018-2383-6 DO - 10.1186/s12906-018-2383-6 ID - Tan2018 ER -