Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach

Table 8 The Glide Scores and IC₅₀ values of acarbose and α-glucosidase inhibitors present in Elaeagnus umbellata Thunb

Compound	α-glucosidae enzyme inhibition (%)^a	GlideScore
Acarbose	–	−7.725
Epigallocatechin gallate	32	−6.283
Quercetin,	28	−6.258
Rutin	15	−5.830
Epigallocatechin	7	−5.550
Catechin hydrate	1	−4.080

The Glide-Scores of compounds: acarbose, epigallocatechin gallate, quercetin, rutin, epigallocatechin and catechin hydrate were found to go in parallel with their experimental α-glucosidase inhibitory activities. All compounds showed weaker inhibitory activity on α-glucosidase except for epigallocatechin gallate. The more negative Glide Score values represent tighter binders ^a [43]

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