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Table 8 The Glide Scores and IC50 values of acarbose and α-glucosidase inhibitors present in Elaeagnus umbellata Thunb

From: Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach

Compound α-glucosidae enzyme inhibition (%)a GlideScore
Acarbose −7.725
Epigallocatechin gallate 32 −6.283
Quercetin, 28 −6.258
Rutin 15 −5.830
Epigallocatechin 7 −5.550
Catechin hydrate 1 −4.080
  1. The Glide-Scores of compounds: acarbose, epigallocatechin gallate, quercetin, rutin, epigallocatechin and catechin hydrate were found to go in parallel with their experimental α-glucosidase inhibitory activities. All compounds showed weaker inhibitory activity on α-glucosidase except for epigallocatechin gallate. The more negative Glide Score values represent tighter binders a [43]