Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach

Table 7 The GlideScores and IC₅₀ values of acarbose and α-amylase inhibitors present in Elaeagnus umbellata Thunb

Compound	α-amylase enzyme inhibition (%)^a	GlideScore
Acarbose	83	−14.158
Rutin	50	−10.434
Quercetin	41	−8.840
Epigallocatechin gallate	21	−7.990
Epigallocatechin	5	−4.550
Catechin hydrate	4	−4.080

Glide Score is an empirical scoring function that estimates the ligand binding free energy, more negative values represent tighter binders. It has been optimized for docking accuracy and binding affinity prediction. Glide Score should be used to rank positions of different ligands in virtual screening. The GlideScore of all compounds were consistent with the inhibitory activities of α-amylase ^a [43]

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