Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach

Table 5 Effect of E. umbellata fruit methanolic extract/fractions on lipid profile in streptozotocin induced diabetic rats

S.No	Groups	Dose (mg/kg)	TC (mg/dl)	TGs (mg/dl)	HDL(mg/dl)	LDL(mg/dl)
1	^aNormal control	0.3 ml	125 ± 6.10**	123.6 ± 8.5**	37 ± 3.1*	74 ± 5.5**
2	^bDiabetic control	0.3 ml	163.3 ± 6.5	165.0 ± 7.9	25.2 ± 2.2	170.4 ± 8.9
3	^cGlibenclamide	0.5	138.5 ± 6.3**	125.3 ± 5.5**	40.5 ± 4.5**	89.3 ± 5.5***
4	^cMe-Ext	100	140.2 ± 5.3*	145.5 ± 7.7*	33.5 ± 4.3*	145.6 ± 4.2*
5	^cMe-Ext	200	131.5 ± 7.5**	138.8 ± 6.5**	36.6 ± 5.5*	93.5 ± 4.6**
6	^cChf-Ext	100	145.4 ± 5.5*	143.2 ± 3.2*	34.2 ± 2.5*	125.3 ± 3.5*
7	^cChf-Ext	200	135.4 ± 5.7**	133.2 ± 5.1**	37.2 ± 3.5*	95.3 ± 3.5**
8	^cEtAC-Ext	100	147.2 ± 5.6*	146.8 ± 4.0*	30.1 ± 4.5*	123.8 ± 6.0*
9	^cEtAC-Ext	200	137.2 ± 7.6**	136.8 ± 5.0**	36.1 ± 5.5*	93.8 ± 8.0**

Each value is mean ± SEM of 8 animals. Comparisons were made between ^anormal control to ^bdiabetic control using student t-test (*p < 0.05, **p < 0.01) and between ^bdiabetic control to positive control ^c(Glibenclamide/extracts) treated groups using one way ANOVA followed by Dunnett’s posthoc multiple comparison test (* p < 0.05,** p < 0.01, ***p < 0.001)

ISSN: 2662-7671