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Table 1 Cardamonin inhibited ATP production and the activity of HK and LDH

From: Glycolysis inhibition via mTOR suppression is a key step in cardamonin-induced autophagy in SKOV3 cells

 

ATP (μmoL/g prot)

HK (U/g prot)

LDH (U/g prot)

Control

94.05 ± 0.94

43.63 ± 3.82

307.28 ± 6.71

Cardamonin (5 μM)

87.69 ± 0.79**

35.58 ± 3.34**

292.94 ± 5.56**

Cardamonin (10 μM)

50.98 ± 1.67**

33.95 ± 3.04**

276.62 ± 4.04**

Cardamonin (20 μM)

29.87 ± 1.31**

27.46 ± 3.60**

225.58 ± 7.50**

Rapamycin (0.1 μM)

56.07 ± 1.47**

34.14 ± 4.90**

286.46 ± 8.68**

2-DG (10 mM)

24.33 ± 1.90**

43.72 ± 3.12

302.43 ± 4.20

  1. SKOV3 cells were treated with cardamonin (5, 10, 20 μM), rapamycin (0.1 μM) and 2-DG (10 mM) for 48 h, respectively. ATP content and the activity of HK and LDH were analyzed by the assay kits, respectively. **p < 0.01 compared to control. Data were represented as mean ± SD, n = 6
  2. 2-DG 2-deoxy-D-glucose, HK hexokinase, LDH lactate dehydrogenase
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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