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Table 4 Correlation between phytochemical content, antioxidant, anti-inflammatory and antiproliferative activity of active extracts

From: Croton gratissimus leaf extracts inhibit cancer cell growth by inducing caspase 3/7 activation with additional anti-inflammatory and antioxidant activities

Cell lines Pearson correlation coefficient (r)
A549 0.3530 0.2404 0.2850 0.4030 0.2525 0.1935
Caco-2 0.0143 0.4529 0.4545 0.2758 0.2820 0.2798
HeLa 0.0920 0.3724 0.3582 0.2043 0.2847 0.2251
MCF-7 0.3111 0.2399 0.0800 0.0003 0.2027 0.2341
  1. Correlation coefficients were determined by plotting a linear curve with IC50 values of extracts obtained for each cancer cell on the y-axis against the corresponding phytochemical content or IC50 values of the antioxidant power (DPPH, ABTS) and anti-inflammatory activity (NO, 15-LOX) on the x-axis. NO: nitric oxide, 15-LOX: 15-lipoxygenase. TPC: total phenolic content, TFC: total flavonoid content, DPPH: 2,2-diphenyl-1-picrylhydrazyl radical, ABTS: 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical