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Table 5 Histopathology and histomorphometry of the femur in sham-operated and OVX mice: Cortical Bones and Osteoclast Cells

From: Anti-osteoporotic effects of mixed compositions of extracellular polymers isolated from Aureobasidium pullulans and Textoria morbifera in ovariectomized mice

Items
Groups
Left femur tissues
Cbt Ocn OS/BS
Controls
 Sham 305.93 ± 46.58 3.00 ± 1.31 3.70 ± 1.94
 OVX 171.11 ± 17.15a 19.63 ± 2.50a 25.29 ± 6.10a
Reference (2.5 mg/kg)
 RES 170.51 ± 11.52a 20.25 ± 4.53a 10.09 ± 1.86ab
Single formula (200 mg/kg)
 EAP 196.82 ± 12.34ab 13.88 ± 2.36ab 15.53 ± 2.37ab
 TM 188.84 ± 9.85ac 13.13 ± 2.10ab 14.48 ± 3.30ab
Mixed formula - EAP:TM (200 mg/kg)
 1:1 195.02 ± 9.43ab 13.50 ± 1.77ab 15.20 ± 1.71ab
 1:3 191.78 ± 9.42ac 13.25 ± 3.15ab 14.79 ± 4.39ab
 1:5 189.98 ± 8.23ac 13.75 ± 1.91ab 16.18 ± 1.78ab
 1:7 190.90 ± 7.34ac 12.50 ± 2.45ab 14.86 ± 2.38ab
 1:9 190.56 ± 10.85ac 13.13 ± 1.73ab 14.93 ± 2.49ab
 3:1 236.15 ± 33.30abde 6.63 ± 1.41abde 7.18 ± 1.41abde
 5:1 194.38 ± 10.32ab 12.50 ± 1.60ab 13.91 ± 2.35ab
 7:1 194.87 ± 10.65ab 12.25 ± 2.71ab 14.02 ± 3.30ab
 9:1 196.31 ± 10.93ab 13.25 ± 2.05ab 15.14 ± 1.73ab
  1. OVX Bilateral ovariectomy, RES Risedronate sodium, EAP Exopolymers purified from A. pullulans SM2001, TM T. morbifera leaf extracts, (EAP:TM) Mixed formula consisted of EAP and TM (g/g), Cbt Cortical bone thickness (Cross thickness; μm), Ocn Osteoclast cell number (Numbers/epiphyseal), OS/BS Osteoclast cell surface/bone surface (%)
  2. Values are expressed mean ± S.D. of eight mice
  3. ap < 0.01 as compared with sham control by MW test
  4. bp < 0.01 and cp < 0.05 as compared with OVX control by MW test
  5. dp < 0.01 as compared with EAP single formula treated mice by MW test
  6. ep < 0.01 as compared with TM single formula treated mice by MW test