BMC Complementary Medicine and Therapies

Table 4 Histopathology and histomorphometry of the femur in sham-operated and OVX mice: Trabecular Bones

From: Anti-osteoporotic effects of mixed compositions of extracellular polymers isolated from Aureobasidium pullulans and Textoria morbifera in ovariectomized mice

Items Groups	Left femur tissues
Items Groups	TV/BV	Tbn	Tbl	Tbt
Controls
Sham	39.33 ± 5.16	18.63 ± 2.56	967.87 ± 131.16	68.48 ± 10.39
OVX	11.33 ± 2.10^e	3.38 ± 1.19^e	318.15 ± 76.18^a	35.91 ± 10.13^e
Reference (2.5 mg/kg)
RES	43.99 ± 7.02^g	27.50 ± 5.53^eg	828.28 ± 109.33^ab	36.51 ± 10.81^e
Single formula (200 mg/kg)
EAP	24.75 ± 2.46^eg	10.50 ± 1.60^eg	594.88 ± 94.79^ab	49.42 ± 2.60^eg
TM	22.77 ± 3.11^eg	8.75 ± 2.96^eg	656.09 ± 127.21^ab	48.86 ± 3.98^eg
Mixed formula - EAP:TM (200 mg/kg)
1:1	24.38 ± 3.73^eg	9.88 ± 2.23^eg	551.50 ± 64.08^ab	48.70 ± 5.40^fh
1:3	23.68 ± 3.09^eg	10.25 ± 1.49^eg	647.64 ± 147.56^ab	49.76 ± 7.89^eh
1:5	22.41 ± 3.53^eg	9.63 ± 1.85^eg	635.86 ± 99.62^ab	52.72 ± 10.21^eg
1:7	23.39 ± 3.11^eg	9.38 ± 1.92^eg	646.56 ± 62.11^ab	49.70 ± 5.97^eg
1:9	23.66 ± 3.97^eg	10.88 ± 2.03^eg	623.38 ± 86.57^ab	52.38 ± 8.86^eg
3:1	35.42 ± 4.00^gij	17.88 ± 1.96^gij	913.57 ± 151.07^bcd	61.78 ± 6.26^hij
5:1	25.06 ± 2.44^eg	10.13 ± 1.25^eg	663.59 ± 89.99^ab	50.78 ± 6.69^eg
7:1	24.39 ± 2.83^eg	10.00 ± 2.00^eg	633.02 ± 77.63^ab	50.30 ± 6.14^eg
9:1	23.79 ± 2.56^eg	10.63 ± 2.67^eg	600.25 ± 96.45^ab	48.45 ± 4.79^eg

OVX Bilateral ovariectomy, RES Risedronate sodium, EAP Exopolymers purified from A. pullulans SM2001, TM T. morbifera leaf extracts, (EAP:TM) Mixed formula consisted of EAP and TM (g/g), TV/BV Trabecular bone volume (%), Tbn Trabecular bone number (Numbers/epiphyseal), Tbl Trabecular bone length (Longitudinal thickness; μm), Tbt Trabecular bone thickness (Cross thickness; μm)
Values are expressed mean ± S.D. of eight mice
^ap < 0.01 as compared with sham control by LSD test
^bp < 0.01 as compared with OVX control by LSD test
^cp < 0.01 as compared with EAP single formula treated mice by LSD test
^dp < 0.01 as compared with TM single formula treated mice by LSD test
^ep < 0.01 and ^fp < 0.05 as compared with sham control by MW test
^gp < 0.01 and ^hp < 0.05 as compared with OVX control by MW test
ⁱp < 0.01 as compared with EAP single formula treated mice by MW test
^jp < 0.01 as compared with TM single formula treated mice by MW test

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ISSN: 2662-7671

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