|
Sample
|
Superoxide anion generationa
|
Elastase releasea
|
|---|
|
IC50 (μΜ)b
|
IC50 (μΜ)b
|
|---|
|
β-amyrin acetate (1)
|
> 10
|
> 10
|
|
scopoletin (4)
|
> 10
|
> 10c
|
|
β-sitosterol-3-O-β-D-glucoside (5)
|
> 10
|
> 10
|
|
dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucoside (6)
|
> 10
|
> 10
|
|
dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside (7)
|
>1d
|
>1d
|
|
genistein
|
1.16 ± 0.12
|
21.51 ± 6.50
|
- aIC50 values, results are presented as mean ± SD (n = 3–4), compared with the control value (formyl-methionyl-leucyl-phenylalanine/cytochalasin B, fMLF/CB)
- bConcentration necessary for 50% inhibition (IC50)
- cScopoletin (4) exerted significant inhibitory activity in elastase release assay (22.8 ± 15.3%, *p < 0.05) at 10 μM
- dDihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside (10) was used at the final concentration of 1 μM due to solubility issues
