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Table 7 Effect of pure compounds on superoxide anion generation and elastase release in fMLF/CB-induced human neutrophils

From: Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

Sample

Superoxide anion generationa

Elastase releasea

IC50 (μΜ)b

IC50 (μΜ)b

β-amyrin acetate (1)

> 10

> 10

scopoletin (4)

> 10

> 10c

β-sitosterol-3-O-β-D-glucoside (5)

> 10

> 10

dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucoside (6)

> 10

> 10

dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside (7)

>1d

>1d

genistein

1.16 ± 0.12

21.51 ± 6.50

  1. aIC50 values, results are presented as mean ± SD (n = 3–4), compared with the control value (formyl-methionyl-leucyl-phenylalanine/cytochalasin B, fMLF/CB)
  2. bConcentration necessary for 50% inhibition (IC50)
  3. cScopoletin (4) exerted significant inhibitory activity in elastase release assay (22.8 ± 15.3%, *p < 0.05) at 10 μM
  4. dDihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside (10) was used at the final concentration of 1 μM due to solubility issues
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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