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Table 5 Cytotoxic activity of the isolated compounds

From: Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

Cell line Conc. (μg/mL) % Inhibition
β-amyrin acetate (1) Scopoletin (4)
HepG2 20 12.1 ± 3.4 11.4 ± 2.1
10 16.0 ± 0.3 6.5 ± 1.2
5 20.4 ± 2.3 0.9 ± 0.1
2.5 8.23 ± 0.7 5.9 ± 1.2
MDA-MB-231 20 −19.6 ± 1.2 8.2 ± 1.0
10 −13.9 ± 1.2 6.0 ± 0.3
5 −5.5 ± 1.2 10.7 ± 9.8
2.5 7.0 ± 0.1 15.5 ± 0.3
A549 20 2.2 ± 0.5 7.9 ± 0.4
10 9.0 ± 1.0 14.9 ± 0.4
5 10.8 ± 0.5 14.6 ± 0.5
2.5 0.4 ± 0.7 14.3 ± 0.7
  1. Results are presented as cell growth inhibition percentage at concentrations of 2.5 to 20 μg/mL, mean ± SD (n = 3). Doxorubicin was used as the positive control and exerted significant cell viability inhibitory effects against HepG2 (IC50 0.49 μg/mL), MDA-MB-231 (IC50 0.68 μg/mL)