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Table 2 Anti-allergic activity of B. rupestris and B. discolor extracts and fractions

From: Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

Sample % viability, RBL-2H3a % inhibition of A23187-induced β-hexosaminidase releaseb
100 μg/mL 10 μg/mL 100 μg/mL
BRT 99.0 ± 1.7 3.0 ± 5.2 25.7 ± 2.1**
BRH 96.7 ± 4.0 3.3 ± 5.8 39.0 ± 13.1**
BRD 95.3 ± 8.1 4.3 ± 7.5 19.0 ± 4.4*
BRE 97.7 ± 4.0 2.0 ± 3.5 7.0 ± 5.2
BRR 99.0 ± 1.7 4.3 ± 5.1 3.7 ± 6.4
BDT 99.0 ± 1.7 3.7 ± 6.4 16.0 ± 5.0*
BDH 99.7 ± 0.6 4.3 ± 7.5 30.3 ± 3.1**
BDD 100.0 ± 0.0 0.0 ± 0.0 44.0 ± 7.8**
BDE 100.0 ± 0.0 1.7 ± 2.9 0.3 ± 0.6
  1. aThe cytotoxicity of samples towards RBL-2H3 cells was evaluated using MTT viability assay and none of the samples showed any toxicity; results are presented as mean ± SD (n = 3)
  2. bDexamethasone (10 nM) was used as the positive control and inhibited 62.0 ± 9.5%** of A23187-induced β-hexosaminidase release in RBL-2H3 cells. Results are presented as mean ± SD (n = 3); *p < 0.05, **p < 0.001 compared with the control value (A23187 only)
  3. BRT B. rupestris total methanol extract, BRH B. rupestris n-hexane fraction, BRD B. rupestris dichloromethane fraction, BRE B. rupestris ethyl acetate fraction, BRR B. rupestris remaining MeOH(aq) fraction, BDT B. discolor total methanol extract, BDH B. discolor n-hexane fraction, BDD B. discolor dichloromethane fraction, BDE B. discolor ethyl acetate fraction