Table 3 The concentrations (ng/mL) of MON and DA in various tissues after oral administration of 100 mg/kg MOIG in male rats (mean ± SD, n = 3)
Tissue/organs | Component | 0.5 h | 1 h | 2 h | 4 h | 8 h | 12 h | 24 h |
|---|---|---|---|---|---|---|---|---|
Small intestine | MON | 162.8 ± 134.4 | 19,075.1 ± 16,724.9 | 3223.4 ± 3453.3 | 69.2 ± 114.2 | 24.6 ± 34.1 | 45.6 ± 78.9 | 0.1 ± 0.1 |
DA | 132.2 ± 101.9 | 13,371.3 ± 11,978.3 | 2053.3 ± 2478.3 | 495.0 ± 838.1 | 110.7 ± 152.2 | 124.9 ± 197.2 | 4.3 ± 6.2 | |
Large intestine | MON | 706.8 ± 659.0 | 924.9 ± 972.6 | 576.9 ± 380.8 | 66.1 ± 79.2 | 58.3 ± 29.9 | 18.6 ± 4.0 | 1.7 ± 3.0 |
DA | 2564.7 ± 3177.5 | 1928.8 ± 1640.6 | 3135.9 ± 2828.6 | 1310.0 ± 2008.0 | 994.9 ± 873.6 | 334.6 ± 69.8 | 26.0 ± 23.5 | |
Stomach | MON | 2888.7 ± 235.2 | 1052.1 ± 402.1 | 364.5 ± 141.9 | 11.7 ± 11.8 | 91.0 ± 21.5 | 12.1 ± 20.9 | 1.0 ± 1.7 |
DA | 2451.1 ± 638.1 | 1124.3 ± 210.2 | 435.1 ± 96.7 | 39.5 ± 21.6 | 84.1 ± 34.5 | 20.9 ± 34.5 | 3.2 ± 5.5 | |
Spleen | MON | 14.6 ± 9.8 | 75.2 ± 71.0 | 5434.0 ± 9376.5 | 66.6 ± 113.9 | 4.6 ± 7.9 | 0.2 ± 0.3 | 49.8 ± 86.2 |
DA | 14.1 ± 8.7 | 58.9 ± 49.4 | 3563.4 ± 6127.5 | 9.5 ± 1.9 | 6.6 ± 6.1 | 3.2 ± 4.6 | 29.6 ± 51.2 | |
Testis | MON | 18.4 ± 3.8 | 16.3 ± 15.3 | 56.6 ± 11.3 | 188.4 ± 304.1 | 304.2 ± 513.5 | 0.0 ± 0.0 | 0.0 ± 0.0 |
DA | 17.1 ± 4.9 | 79.1 ± 67.0 | 69.1 ± 11.2 | 24.8 ± 5.6 | 221.0 ± 358.6 | 0.0 ± 0.0 | 0.8 ± 1.3 | |
Heart | MON | 24.3 ± 10.6 | 545.5 ± 908.9 | 8.9 ± 1.9 | 0.0 ± 0.0 | 0.2 ± 0.3 | 0.0 ± 0.0 | 269.2 ± 466.2 |
DA | 22.7 ± 7.4 | 533.2 ± 856.8 | 28.9 ± 0.8 | 10.0 ± 1.9 | 2.2 ± 1.9 | 0.0 ± 0.0 | 214.3 ± 371.2 | |
Kidney | MON | 48.6 ± 19.5 | 147.8 ± 109.9 | 30.7 ± 4.3 | 17.0 ± 4.3 | 3.5 ± 1.7 | 4.2 ± 7.2 | 0.0 ± 0.0 |
DA | 91.7 ± 15.9 | 303.2 ± 162.0 | 220.2 ± 19.4 | 202.2 ± 40.2 | 66.1 ± 6.5 | 31.5 ± 18.8 | 2.5 ± 4.4 | |
Marrow | MON | 82.8 ± 46.8 | 24.2 ± 23.6 | 10.1 ± 2.9 | 5.8 ± 6.6 | 1.2 ± 2.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
DA | 102.7 ± 90.0 | 37.8 ± 21.0 | 24.8 ± 5.1 | 11.4 ± 3.3 | 5.6 ± 7.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Liver | MON | 15.6 ± 7.0 | 26.5 ± 7.9 | 20.3 ± 5.2 | 10.3 ± 3.9 | 12.6 ± 9.3 | 20.4 ± 35.3 | 0.0 ± 0.0 |
DA | 17.5 ± 2.4 | 46.9 ± 15.9 | 52.0 ± 7.6 | 35.4 ± 7.7 | 20.9 ± 5.4 | 22.9 ± 31.9 | 0.0 ± 0.0 | |
Lung | MON | 58.9 ± 29.3 | 28.7 ± 23.1 | 34.7 ± 13.9 | 9.5 ± 6.3 | 2.0 ± 0.3 | 64.3 ± 96.8 | 0.0 ± 0.0 |
DA | 47.5 ± 23.8 | 47.1 ± 8.6 | 48.5 ± 10.5 | 23.9 ± 2.5 | 6.4 ± 0.7 | 72.4 ± 116.7 | 3.9 ± 6.7 | |
Thymus | MON | 16.8 ± 11.5 | 11.6 ± 3.8 | 13.0 ± 2.8 | 13.0 ± 11.1 | 6.4 ± 1.3 | 0.0 ± 0.0 | 0.0 ± 0.0 |
DA | 22.7 ± 14.6 | 23.0 ± 3.5 | 29.7 ± 5.0 | 10.1 ± 1.9 | 4.5 ± 3.2 | 0.8 ± 1.4 | 1.5 ± 2.0 | |
Hypothalamus | MON | 152.5 ± 76.3 | 110.3 ± 58.0 | 122.7 ± 137.7 | 27.7 ± 39.7 | 16.4 ± 14.2 | 0.0 ± 0.0 | 0.0 ± 0.0 |
DA | 101.0 ± 19.9 | 70.9 ± 27.6 | 74.7 ± 88.3 | 32.5 ± 29.7 | 17.1 ± 14.9 | 4.8 ± 8.3 | 2.6 ± 4.6 |