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Table 1 Data of 16 included studies

From: Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis

Trial Species(Na/Nc) Age(month) Weigh(g) Model Acupuncture(acupoints) Control intervention Outcome assessment Result
Wang 2004 [11] SD rats (14/13)
SD rats (14/13)
2~ 3 200–250 4-VO EA,20 min/d for 15d, 150HZ, 2 mA, continuous
Waveform (GV14, GV20)
No treatment
Nimodipine
Escape latency
Escape latency
P < 0.01
P > 0.05
Yu 2005 [12] Wistar rats
(15/14)
NR 340 ± 40 EO manual acupuncture,
30 s/d for 21 d (CV6, CV12, CV17, SP10, ST36)
Placebo-acupuncture Escape latency
Duration in former platform position
Frequency crossing former platform
P < 0.05
P < 0.05
P < 0.05
Shao 2008 [13] SD rats (9/8)
SD rats (9/8)
NR 180–220 4-VO EA,20 min/d for 15 d, 150 HZ, 1–2 mA, Continuous
Waveform (BL17, BL20, BL23, GV20)
No treatment
Nimodipine
Escape latency
Escape latency
P < 0.01
P > 0.05
Wang 2009 [14] Wistar rats(11/11) 10 300 ± 40 EO manual acupuncture, 30 s/d for 21 d (CV6, CV12, CV17, SP10, ST36) Placebo-acupuncture Escape latency
Duration in former platform position
P < 0.05
P < 0.01
Wei 2011 [15] SD rats(10/10) NR 200–250 2-VO EA, 20 min/d for 10 d, 50 HZ,1.0 mA, continuous Waveform (GV14, GV20) No treatment
Nimodipine
Escape latency
Frequency crossing former platform
Escape latency
Frequency crossing former platform
P < 0.01
P < 0.01
P > 0.01
P > 0.01
Zhao 2011 [16] Wistar rats(10/10) 4 240 ± 20 EO manual acupuncture, 30 s/d for 21 d(CV6, CV12, CV17, SP10, ST36) Placebo-acupuncture Escape latency
Swimming Speed
P < 0.01
P > 0.05
Zhu 2011 [17] SD rats(11/12) 9 460 ± 30 2-VO EA, 20 min/d for 30 d,4HZ, 2.0 mA, continuous waveform (BL23, GV14, GV20) No treatment Escape latency P < 0.01
Zhu 2012 [18] SD rats(12/10) 12 400 ± 30 2-VO EA, 20 min/d for 30 d,4 HZ, 2.0 mA, continuous waveform (BL23, GV14, GV20) No treatment Escape latency P < 0.05
Zhu 2013 [19] SD rats(6/6) NR 432 ± 30 2-VO EA, 20 min/d for 30 d, 4HZ, continuous waveform (BL23, GV14, GV20) No treatment Escape latency P < 0.05
Yang 2014 CG [20] Wistar rats (12/12) NR 200–250 2-VO manual acupuncture, 360 min/d for 21 d (Frontal region, frontoparietal region and parietal region) No treatment Escape latency
Swimming distance
P < 0.05
P < 0.05
Yang 2014 CG [20] Wistar rats (12/12) NR 200–250 2-VO manual acupuncture, 360 min/d for 21 d (Frontal region, frontoparietal region and parietal region) No treatment Escape latency
Swimming distance
P < 0.05
P < 0.05
Zhang 2014 [21] Wistar rats (10/10) NR 300–320 EO manual acupuncture, 30 s/d for 21 d (CV6, CV12, CV17, SP10, ST36) Placebo-acupuncture Escape latency
Frequency crossing former platform
Duration in former platform position
P < 0.01
P < 0.01
P < 0.01
Li 2015 [22] Wistar rats (11/11) NR 320–360 EO manual acupuncture,30 s/d for 14 d (ST36) Placebo-acupuncture Escape latency P < 0.05
Li 2015 [23] Wistar rats (10/10) 2 300–320 EO manual acupuncture, 30 s/d for 14 d (ST36 Placebo-acupuncture Escape latency P < 0.05
Wang 2015 [24] Wister rats(10/10) NR 200–220 2-VO manual acupuncture, 30 s/d for 21 d (CV6, CV12, CV17, SP10, ST36) Placebo-acupuncture Escape latency
Swimming speed
Duration in former platform position
P < 0.05
P > 0.05
P < 0.05
Fang 2016 [25] SD rats(18/18) 9 300–450 MCAO EA, 20 min/d for 30 d, 30HZ, 6-15 V, sparse wave (BL23, GV14, GV20) No treatment Escape latency P < 0.05
Li 2016 [26] Wister rats (14/14) NR 270–320 2-VO manual acupuncture, 30 s/d for 14 d (ST36) Placebo-acupuncture Escape latency
Duration in former platform position
Swimming speed
P < 0.01
P < 0.01
P > 0.05
  1. Na number of animals in the acupuncture group, EA electroacupuncture, Nc number of animals in the control group, SD Sprague Dawley, 4-VO 4-vessel occlusion, EO embolic occlusion, 2-VO bilateral common carotid artery occlusion, NR no record, PG positive control group, CG cluster-needling group, MCAO middle cerebral artery occlusion