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Table 4 Changes in the Nutritional Hematological and Inflammation Biomarkers

From: Effects of acupuncture on nutritional state of patients with stable chronic obstructive pulmonary disease (COPD): re-analysis of COPD acupuncture trial, a randomized controlled trial

  Baseline After 12 weeks Change from baseline to post treatment measurements MD 95% CI Effect size (d)
Nutritional Hematological
RBP (mg/dL)
 PAG (n 20) 3.0 [0.7] 3.0 [0.6] 0.02 [0.5] 0.98 0.48, 1.46 1.60
 RAG (n 22) 3.3 [1.5] 4.3 [1.3] 1.0 [0.7]
PA (mg/dL)
 PAG (n 32) 23.4 [3.7] 22.9 [4.6] −0.5 [2.6] 2.84 0.93, 4.76 0.77
 RAG (n 30) 23.0 [4.9] 25.4 [6.7] 2.4 [4.7]
Tf (mg/dL)
 PAG (n 20) 218.9 [76.6] 208.0 [67.9] −10.9 [8.8] 54.1 34.53, 71.82 2.94
 RAG (n 22) 216.4 [38.1] 259.6 [45.0] 43.2 [24.0]
Hb (g/dL)
 PAG (n 32) 14.1 [1.1] 13.9 [1.2] −0.2 [0.9] 0.90 0.54, 1.27 1.17
 RAG (n 30) 13.9 [1.6] 14.6 [1.3] 0.7 [0.6]
Inflammation Biomarkers
Hs-CRP (ng/mL)
 PAG (n 12) 735.3 [445.6] 717.8 [396.6] −17.4 [71.7] − 576.58 − 610.60, −44.23 1.57
 RAG (n 10) 1109.3 [437.2] 515.3 [247.6] − 594.0 [542.4]
TNF-α (pg/mL)
 PAG (n 12) 2.5 [0.9] 2.8 [1.0] 0.4 [0.8] −2.09 −2.44, −0.42 1.56
 RAG (n 10) 3.3 [1.5] 1.6 [1.2] −1.7 [1.8]
IL-6 (pg/mL)
 PAG (n 12) 2.9 [1.0] 3.6 [1.4] 0.7 [1.5] −2.34 −3.13, −0.87 1.55
 RAG (n 10) 3.3 [1.1] 1.7 [1.0] −1.7 [1.6]
SAA (μg/mL)
 PAG (n 12) 5.0 [1.7] 5.5 [2.4] 0.5 [1.0] −2.10 −3.34, −1.02 1.75
 RAG (n 10) 4.4 [1.7] 2.7 [0.8] −1.6 [1.4]
COHb (%)
 PAG (n 32) 1.4 [1.0] 1.9 [1.1] 0.5 [0.9] −1.13 −1.51, −0.69 1.10
 RAG (n 30) 1.4 [1.2] 0.8 [0.6] −0.6 [1.1]
  1. MD mean difference, RBP Retinol-Binding Protein, PA Pre-Albumin, Tf Transferrin, Hb Hemoglobin, Hs-CRP High sensitivity C-reactive protein, TNF-α Tumor Necrosis Factor-alpha, IL-6 Interleukin 6, SAA Serum Amyloid A, COHb carboxyhemoglobin