The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

Table 1 Effect of MECN on hole cross test

Treatment	Dose (mg/kg)	Number of hole crossed (% of Inhibition)
Treatment	Dose (mg/kg)	Pretreatment	30 min	60 min	90 min	120 min
Control	0.1 ml/mouse	23.40 ± 1.21	18.60 ± 1.44	18.20 ± 1.36	17.00 ± 1.22	15.60 ± 1.08
Diazepam	1	21.40 ± 2.32	6.20 ± 1.07*** (66.67)	3.80 ± 0.58*** (79.12)	2.60 ± 0.51*** (84.71)	1.40 ± 0.24*** (91.03)
MECN	50	22.80 ± 1.28	15.40 ± 0.93 (17.20)	11.80 ± 0.73*** (35.16)	7.80 ± 0.86*** (54.12)	6.00 ± 0.71*** (61.54)
MECN	100	20.60 ± 1.86	10.60 ± 0.75*** (43.01)	9.00 ± 0.71*** (50.55)	4.60 ± 0.93*** (72.94)	3.80 ± 0.86*** (75.64)
MECN	200	21.20 ± 1.85	8.00 ± 0.71*** (56.99)	5.20 ± 0.73*** (71.43)	2.40 ± 0.51*** (85.88)	1.60 ± 0.24*** (89.74)

Effect of MECN on hole cross test. Values are presented as the Mean ± SEM (n = 5). MECN = Methanolic extract of Crataeva nurvala; ***p < 0.001 compared with the control group (two-way ANOVA followed by Bonferroni’s test)

ISSN: 2662-7671