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Table 3 Antifungal activity of solvent extracts and fractions of T. diversifolia and T. rotundifolia

From: A comprehensive study of the potential phytomedicinal use and toxicity of invasive Tithonia species in South Africa

Plant species

Extract/fraction

MIC (mg/ml)

 

A. fumigatus

C. neoformans

C. albicans

48 h

72 h

48 h

72 h

48 h

72 h

T. diversifolia

Ethanol

2.5

1.25

0.07*

2.5

2.5

2.5

Methanol

0.62

0.62

0.07*

0.62

2.5

2.5

DCM

0.62

1.25

0.15

0.31

2.5

2.5

Acetone

0.15

0.31

0.07*

0.15

0.15

0.62

Hot water

0.62

0.62

0.15

1.25

1.25

1.25

Hexaane

0.15

0.15

0.03**

0.07*

1.25

1.25

Chloroform

0.31

1.25

0.15

0.31

1.25

1.25

ETAC

2.5

2.5

0.31

1.25

0.15

0.15

T. rotundifolia

Ethanol

1.25

1.25

0.15

0.62

1.25

1.25

Methanol

0.62

1.25

0.31

0.62

2.5

2.5

DCM

0.15

1.25

0.07*

0.15

0.07*

0.15

Acetone

0.07*

1.25

0.07*

0.15

0.07*

0.15

Hot water

2.5

> 2.5

0.62

2.5

> 2.5

> 2.5

Hexane

0.31

1.25

0.62

1.25

0.15

0.15

Chloroform

> 2.5

0.62

1.25

1.25

0.31

0.62

Butanol

> 2.5

> 2.5

0.31

0.31

1.25

1.25

ETAC

> 2.5

1.25

0.15

0.62

0.15

0.62

Amp B (+ve con)

 

0.03**

0.62

0.008**

0.125

0.03**

0.50

  1. DCM dichloromethane, ETAC ethyl acetate fraction, Amp Amphotericin B, +ve positive control, A. fumigatus Aspergillus fumigatus, C. neoformans Cryptococcus neoformans; C. albicans Candida albicans
  2. Values written in bold with no asterisk are considered as moderate; Values written in bold with one asterisk are considered active; Values written in bold with two asterisks are considered very active; Values greater than 0.1 mg/ml but less than 2.5 mg/ml are considered as weak activity, while values greater than 2.5 mg/ml are considered not active
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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