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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective

Fig. 5

B-TCE pretreatment promoted plasticity, neurite outgrowth and migration and protected from glutamate-induced excitotoxicity. a) Confocal micrographs of Control, Glutamate (2 mM), B-TCE (20 μg/mL) and B-TCE + Glu treated primary cerebellar neurons immunostained for PSA-NCAM and NCAM. Nuclei were stained with DAPI (third panel). The fourth panel represents the overlay of above three panels. b) Representative immunoblots and histograms representing relative expression PSA-NCAM and NCAM where α-Tubulin was used as internal control. c) Overlay confocal micrographs of primary cerebellar explants stained for PSA-NCAM, NCAM and DAPI. Data was compared between Control and other groups such as Glutamate, B-TCE and B-TCE + Glu (*p ≤ 0.01) as well as Glutamate alone with B-TCE and B-TCE + Glu groups (#p ≤ 0.01). Confocal Images were captured at 60X objective (Scale bar: 50 μm)

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