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Table 1 Concentration parameters of the selected plant extracts on MIA PaCa-2 cell line sensitivity depending on the extraction method

From: Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts

  

Extraction Method

SFE

UAE

Commercial

Concentration Parameter

 

RVM

OVM

 

Plant extract

  

Ethanol

Ethanol:Water

Ethanol

Ethanol:Water

 

Marjoram

IC50

>  100a

>  100a

>  100a

>  100

GI50

>  100

75,89 ± 2,05

>  100

>  100

TGI

>  100

>  100

>  100

>  100

LC50

>  100

>  100

>  100

>  100

Balm

IC50

>  100a

>  100a

>  100a

>  100

GI50

>  100

>  100

>  100

>  100

TGI

>  100

>  100

>  100

>  100

LC50

>  100

>  100

>  100

>  100

Yarrow

IC50

31,4 ± 8,5a

48,5 ± 2,5a

>  100

28,8 ± 15,8

>  100

>  500

GI50

37,4 ± 7,3

> 100

>  100

49,4 ± 25,7

>  100

>  500

TGI

56 ± 1,4

65,1 ± 6,1

>  100

86,6 ± 3,4

>  100

>  500

LC50

70,6 ± 7,1

> 100

>  100

> 100

>  100

>  500

Marigold

IC50

39,8 ± 4,6a

>  100a

>  100a

>  100

>  500

GI50

>  100

>  100

>  100

>  500

TGI

54, ± 3,1

>  100

>  100

>  100

>  500

LC50

78,5 ± 1,4

>  100

>  100

>  100

>  500

  1. Data (> 100): not significant activity found at 100 μg/mL concentration; (−): not determined; SFE Supercritical Fluid Extraction, UAE Ultrasound Assisted Extraction, RVM Residual Vegetable Matrix, OVM Original Vegetable Matrix. aData acquired from a previous work [4]
  2. Data are presented as IC50 (μg/mL) (concentration needed to induce 50% cell viability inhibition [4, 5] <sup> 5</sup>, GI50 (μg/mL) (concentration needed for 50% growth inhibition), TGI (μg/mL) (concentration needed for total growth inhibition) and LC50 (μg/mL) (concentration needed for 50% cell death) after 48 h treatment as mean ± SEM of at least three independent experiments each performed in quadruplicate