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Table 1 Concentration parameters of the selected plant extracts on MIA PaCa-2 cell line sensitivity depending on the extraction method

From: Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts

   Extraction Method
SFE UAE Commercial
Concentration Parameter   RVM OVM  
Plant extract    Ethanol Ethanol:Water Ethanol Ethanol:Water  
Marjoram IC50 >  100a >  100a >  100a >  100
GI50 >  100 75,89 ± 2,05 >  100 >  100
TGI >  100 >  100 >  100 >  100
LC50 >  100 >  100 >  100 >  100
Balm IC50 >  100a >  100a >  100a >  100
GI50 >  100 >  100 >  100 >  100
TGI >  100 >  100 >  100 >  100
LC50 >  100 >  100 >  100 >  100
Yarrow IC50 31,4 ± 8,5a 48,5 ± 2,5a >  100 28,8 ± 15,8 >  100 >  500
GI50 37,4 ± 7,3 > 100 >  100 49,4 ± 25,7 >  100 >  500
TGI 56 ± 1,4 65,1 ± 6,1 >  100 86,6 ± 3,4 >  100 >  500
LC50 70,6 ± 7,1 > 100 >  100 > 100 >  100 >  500
Marigold IC50 39,8 ± 4,6a >  100a >  100a >  100 >  500
GI50 >  100 >  100 >  100 >  500
TGI 54, ± 3,1 >  100 >  100 >  100 >  500
LC50 78,5 ± 1,4 >  100 >  100 >  100 >  500
  1. Data (> 100): not significant activity found at 100 μg/mL concentration; (−): not determined; SFE Supercritical Fluid Extraction, UAE Ultrasound Assisted Extraction, RVM Residual Vegetable Matrix, OVM Original Vegetable Matrix. aData acquired from a previous work [4]
  2. Data are presented as IC50 (μg/mL) (concentration needed to induce 50% cell viability inhibition [4, 5] <sup> 5</sup>, GI50 (μg/mL) (concentration needed for 50% growth inhibition), TGI (μg/mL) (concentration needed for total growth inhibition) and LC50 (μg/mL) (concentration needed for 50% cell death) after 48 h treatment as mean ± SEM of at least three independent experiments each performed in quadruplicate