Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats

Yun, Jun-Won; Kwon, Euna; Kim, Yun-Soon; Kim, Seung-Hyun; You, Ji-Ran; Kim, Hyoung-Chin; Park, Jin-Sung; Che, Jeong-Hwan; Lee, Sang-Koo; Jang, Ja-June; Kim, Hyeon Hoe; Kang, Byeong-Cheol

doi:10.1186/s12906-018-2315-5

BMC Complementary Medicine and Therapies

Table 4 Results of microscopic observation of F344 rats orally administered with Tiglium seed extract for 13 weeks

From: Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats

		Dose of Tiglium seed (mg/kg)								Dose of Tiglium seed (mg/kg)
		Male			Female					Male			Female
		0^a	250	500	0	250	500			0	250	500	0	250	500
Liver	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Duodenum	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Kidney	Normal	4/10	5/10	8/10	9/10	8/10	9/10	Jejunum	Normal	10/10	10/10	10/10	10/10	10/10	10/10
	Tubular calcification	0/10	0/10	0/10	1/10	2/10	1/10	Ileum	Normal	10/10	10/10	10/10	10/10	10/10	10/10
	Basophilic tubule	6/10	5/10	2/10	0/10	0/10	0/10	Colon	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Thyroid gland	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Rectum	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Urinary bladder	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Preputial/Clitoral gland	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Spleen	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Skin/ Mammary gland	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Pancreas	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Eye	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Thymus	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Harderian gland	Normal	8/10	10/10	10/10	10/10	4/10	9/10
Thyroid gland	Normal	10/10	10/10	10/10	10/10	10/10	10/10		Inflammation	0/10	0/10	0/10	0/10	1/10	0/10
Parathyroid gland	Normal	10/10	10/10	10/10	10/10	10/10	10/10		Focal inflammation	2/10	0/10	0/10	0/10	5/10	1/10
Trachea	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Brain	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Esophagus	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Pituitary gland	Normal	10/10	10/10	10/10	10/10	10/10	10/10
Lung	Normal	0/10	0/10	2/10	3/10	1/10	2/10	Femur/Bone marrow	Normal	10/10	10/10	10/10	10/10	10/10	10/10
	Focal inflammation	10/10	10/10	8/10	3/10	8/10	8/10	Nasal cavity	Normal	10/10	10/10	10/10	10/10	10/10	10/10
	Pneumonia	0/10	0/10	0/10	4/10	1/10	0/10	Testis	Normal	10/10	10/10	10/10	–	–	–
Heart	Normal	0/10	4/10	3/10	7/10	8/10	8/10	Epididymis	Normal	10/10	10/10	10/10	–	–	–
	Focal inflammation	9/10	6/10	7/10	3/10	2/10	2/10	Prostate	Normal	10/10	10/10	10/10	–	–	–
	Focal myocarditis	1/10	0/10	0/10	0/10	0/10	0/10	Seminal vesicle	Normal	10/10	10/10	10/10	–	–	–
Salivary gland	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Ovary	Normal	–	–	–	10/10	10/10	10/10
Cervical lymph node	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Uterus	Normal	–	–	–	10/10	10/10	10/10
Mesenteric lymph node	Normal	10/10	10/10	10/10	10/10	10/10	10/10	Vagina	Normal	–	–	–	10/10	10/10	10/10
Stomach	Normal	10/10	10/10	10/10	10/10	10/10	10/10

^aControl group

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ISSN: 2662-7671

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