Skip to main content

Table 3 Summary of findings of CAM for childhood atopic eczema in randomized controlled trials

From: Complementary and alternative medicine for treatment of atopic eczema in children under 14 years old: a systematic review and meta-analysis of randomized controlled trials

Study ID Sample size Main intervention Estimate effect [95% CI] Outcome P
CAM vs usual care
 Liu CH 2009 [20] T:150 C:148 Swimming therapy RR 1.01 [0.92, 1.11]
RR 1.01 [0.96, 1.07]
RR 0.38 [0.28, 0.52]
Clinical effectiveness rate
50% Improvement of symptoms and signs
Relapse rate
P = 0.8318
P = 0.5671
P < 0.00001
 Liu WQ 2016 [21] T:60 C:60 Fasting and Rotation diet RR 1.57 [1.04, 2.38]
RR 1.32 [1.09, 1.60]
RR 0.36 [0.12, 1.08]
Clinical effectiveness
50% Improvement of symptoms and signs;
Relapse rate
P = 0.0323
P = 0.0049
P = 0.0681
 Wu YQ 2014 [22] T:74 C:74 Velvetfeeling lotion (external application) RR 1.92 [1.36, 2.72]
RR 1.33 [1.10, 1.61]
Clinical effectiveness rate
50% Improvement of symptoms and signs
P = 0.0002
P = 0.0031
CAM + usual care vs usual care
 Chen DX 2015 [23] T:20 C:20 Bifid Triple Viable capsules (oral) RR 1.63 [0.87, 3.04]
RR 1.73 [1.15, 2.60]
Clinical effectiveness rate
50% Improvement of symptoms and signs
P = 0.1283
P = 0.0088
 Chen YL 2015 [24] T:58 C:58 Probiotics (oral) RR 1.21 [0.87, 1.68]
RR 1.19 [0.99, 1.42]
RR 0.31 [0.16, 0.60]
Clinical effectiveness rate
50% Improvement of symptoms and signs
Relapse rate
P = 0.2659
P = 0.0624
P = 0.0004
 Guo YH 2015 [25] T:90 C:90 Tetralogy of viable bifidobacterium tablets (oral) RR 1.37 [1.01, 1.85]
RR 1.27 [1.04, 1.55]
RR 0.39 [0.27, 0.56]
Clinical effectiveness rate
50% Improvement of symptoms and signs
Relapse rate
P = 0.0400
P = 0.0172
P < 0.00001
 Jiang YX 2013 [26] T:65 C:60 Velvetfeeling lotion (external application) RR 1.85 [0.90, 3.79]
RR 1.91 [1.46, 2.50]
Clinical effectiveness rate
50% Improvement of symptoms and signs
P = 0.0947
P < 0.00001
 Li DY 2012 [27] T:32 C:30 Bifid Triple Viable capsules (oral) RR 1.36 [1.03, 1.79]
RR 1.32 [1.06, 1.65]
RR 0.28 [0.13, 0.60]
Clinical effectiveness rate
50% Improvement of symptoms and signs;
Relapse rate
P = 0.0295
P = 0.0151
P = 0.0011
 Mao HX 2013 [28] T:50 C:50 Probiotics (oral) RR 0.17 [0.04, 0.71] Relapse rate P = 0.0151
 Wei MX 2010 [29] T:38 C:36 Viable Bacillus Coagulans tablets (oral) RR 1.33 [1.05, 1.68]
RR 1.30 [1.07, 1.58]
RR 0.28 [0.14, 0.56]
Clinical effectiveness rate
50% Improvement of symptoms and signs;
Relapse rate
P = 0.0189
P = 0.0089
P = 0.0004
 Ye CQ 2017 [30] T:48 C:48 Condensation living bacterium bacillus (oral) RR 1.57 [1.21, 2.02]
RR 1.31 [1.10, 1.55]
RR 0.21 [0.10, 0.47]
Clinical effectiveness rate
50% Improvement of symptoms and signs;
Relapse rate
P = 0.0005
P = 0.0019
P = 0.0001
 Zhang MH 2013 [31] T:35 C:35 Bifico Lriple Viable (oral) RR 1.15 [0.91, 1.46]
RR 0.38 [0.17, 0.85]
50% Improvement of symptoms and signs;
Relapse rate
P = 0.2371
P = 0.0180
 Zhang XN 2013 [32] T:36 C:34 Velvetfeeling lotion (external application) RR 6.61 [1.62, 26.96]
RR 1.25 [1.00, 1.56]
Clinical effectiveness rate
50% Improvement of symptoms and signs
P = 0.0084
P = 0.0542
CAM vs placebo
 Reza 2011 [35] T:19 C:21 Synbiotic (oral) MD 19.10 [7.60, 30.60] Clinical effectiveness scores P = 0.0017
 Sergei V. Gerasimov 2010 [37] T:48 C:48 Probiotics (oral) MD 6.40 [2.71, 10.09] Clinical effectiveness scores P = 0.0009
 Wu YJ 2017 [39] T:33 C:33 Probiotics (Lactobacillus rhamnosus) (oral) MD 10.85 [3.82, 17.88] Clinical effectiveness scores P = 0.0035
 Yavuz 2012 [40] T:20 C:20 Probiotic (oral) MD 10.20 [7.45, 12.95] Clinical effectiveness scores P < 0.00001
 Youngshin 2012 [41] T:58 C:60 Probiotics (L. plantarum CJLP133) (oral) MD 7.30 [2.63, 11.97] Clinical effectiveness scores P = 0.0029
  1. CAM complementary and alternative medicine, RR risk ratio, MD mean difference, CI confidence interval