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Table 5 Cytotoxic effects of tested compounds

From: Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation

  IC50 (μM)
Isolated compounds MCF-7 MDA MB 231 A2780 A2780 CP HepG2 HCT-116
Cucurbitacin E (1) 7.2 2.1 5.4 15.9 3.4 3.4
Cucurbitacin B (2) 16.0 0.96 7.6 14.2 1.7 1.7
Hexanor-Cucurbitacin D (3) 47.9 12.0 > 100 > 100 37.8 30.7
Cucurbitacin D (4) 26.7 4.0 21.6 6.9 5.0 7.6
Cucurbitacin F 25-O-acetate (5) 18.4 3.4 15.8 15.2 10.2 11.2
Dihydrocucurbitacin D (6) > 100
Isocucurbitacin D (7) 1.0
Cucurbitacin E glucoside (8) 27.3
  1. Inhibitory effects of compounds from the ethyl acetate extract fraction of Cucumis prophetarum var. prophetarum fruits on the proliferation of MCF7, MDA-MB-231, HCT-116, A2780, A2780CP, and HepG2. Cell were treated with 0–100 μM. a IC50 is the concentration that inhibited cell proliferation by 50%. n = 8