| IC50 (μM) | |||||
---|---|---|---|---|---|---|
Isolated compounds | MCF-7 | MDA MB 231 | A2780 | A2780 CP | HepG2 | HCT-116 |
Cucurbitacin E (1) | 7.2 | 2.1 | 5.4 | 15.9 | 3.4 | 3.4 |
Cucurbitacin B (2) | 16.0 | 0.96 | 7.6 | 14.2 | 1.7 | 1.7 |
Hexanor-Cucurbitacin D (3) | 47.9 | 12.0 | > 100 | > 100 | 37.8 | 30.7 |
Cucurbitacin D (4) | 26.7 | 4.0 | 21.6 | 6.9 | 5.0 | 7.6 |
Cucurbitacin F 25-O-acetate (5) | 18.4 | 3.4 | 15.8 | 15.2 | 10.2 | 11.2 |
Dihydrocucurbitacin D (6) | – | > 100 | – | – | – | – |
Isocucurbitacin D (7) | – | 1.0 | – | – | – | – |
Cucurbitacin E glucoside (8) | – | 27.3 | – | – | – | – |