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Table 5 Cytotoxic effects of tested compounds

From: Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation

 

IC50 (μM)

Isolated compounds

MCF-7

MDA MB 231

A2780

A2780 CP

HepG2

HCT-116

Cucurbitacin E (1)

7.2

2.1

5.4

15.9

3.4

3.4

Cucurbitacin B (2)

16.0

0.96

7.6

14.2

1.7

1.7

Hexanor-Cucurbitacin D (3)

47.9

12.0

> 100

> 100

37.8

30.7

Cucurbitacin D (4)

26.7

4.0

21.6

6.9

5.0

7.6

Cucurbitacin F 25-O-acetate (5)

18.4

3.4

15.8

15.2

10.2

11.2

Dihydrocucurbitacin D (6)

–

> 100

–

–

–

–

Isocucurbitacin D (7)

–

1.0

–

–

–

–

Cucurbitacin E glucoside (8)

–

27.3

–

–

–

–

  1. Inhibitory effects of compounds from the ethyl acetate extract fraction of Cucumis prophetarum var. prophetarum fruits on the proliferation of MCF7, MDA-MB-231, HCT-116, A2780, A2780CP, and HepG2. Cell were treated with 0–100 μM. a IC50 is the concentration that inhibited cell proliferation by 50%. n = 8