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Table 6 Pharmacological interactions among terpenes derived from L. alba

From: Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide)

Parasitic Form Limonene + Compound ΣFICf μg/mL ± SDg Pharmacological interaction
Epia CarOxd 0.5 ± 0.13 Synergism
Carvone 1.1 ± 0.08 Antagonism
Citral 0.7 ± 0.13 Synergism
BNZe 0.4 ± 0.13 Synergism
Trypb CarOxd 0.4 ± 0.10 Synergism
Carvone 1.04 ± 0.04 Antagonism
Citral 0.6 ± 0.10 Synergism
BNZe 0.4 ± 0.10 Synergism
Amasc CarOxd 0.7 ± 0.23 Synergism
Carvone NDh NDh
Citral 0.8 ± 0.15 Synergism
BNZe 0.6 ± 0.13 Synergism
Vero CarOxd 1.2 ± 0.16 Antagonism
Carvone 1.0 ± 0.07 Additive
Citral 1.0 ± 0.07 Antagonism
BNZe 0.5 ± 0.18 Synergism
  1. aEpi Epimastigote, bTryp Trypomastigote, cAmas Amastigote, dCarOx Caryophyllene oxide, eBNZ Benznidazole, fFIC Fractional inhibitory concentration, gSD Standard deviation, hND Not determinated