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Table 5 Anti-parasitic effect on Trypanosoma cruzi of the major terpenes of Citral and Carvone chemotype L. alba essential oils

From: Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide)

Terpenes

Epia IC50b ± SDc (μg/mL)

SId

Trype IC50b ± SDc (μg/mL)

SId

Amash IC50b ± SDc (μg/mL)

SId

Vero CC50i ± SDc (μg/mL)

CarOxj

30 ± 1.7

4.3

22 ± 0.3

5.9

47 ± 1.0

2.7

128 ± 4.2

Limonene

42 ± 2.5

7.1

9 ± 0.8

32.8

29 ± 0.7

10.3

297 ± 2.4

Citral

37 ± 0.7

2.4

21 ± 1

4.3

49 ± 2.3

1.8

90 ± 3.9

Carvone

177 ± 7.9

1.4

124 ± 8

1.9

>  100

NDl

240 ± 4.1

BNZk

17 ± 0.9

8.2

1.2 ± 0.1

116.3

6.2 ± 0.9

22.4

139 ± 2.3

  1. aEpi Epimastigote, bIC50 Inhibitory concentration 50, cSD Standard deviation, dSI Selectivity index (CC50/IC50), gTryp Trypomastigote, hAmas Amastigote, iCC50 Cytotoxic concentration 50, jCarOx Caryophyllene oxide, kBNZ Benznidazole, lND Not determinated
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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