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Table 5 Anti-parasitic effect on Trypanosoma cruzi of the major terpenes of Citral and Carvone chemotype L. alba essential oils

From: Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide)

Terpenes Epia IC50b ± SDc (μg/mL) SId Trype IC50b ± SDc (μg/mL) SId Amash IC50b ± SDc (μg/mL) SId Vero CC50i ± SDc (μg/mL)
CarOxj 30 ± 1.7 4.3 22 ± 0.3 5.9 47 ± 1.0 2.7 128 ± 4.2
Limonene 42 ± 2.5 7.1 9 ± 0.8 32.8 29 ± 0.7 10.3 297 ± 2.4
Citral 37 ± 0.7 2.4 21 ± 1 4.3 49 ± 2.3 1.8 90 ± 3.9
Carvone 177 ± 7.9 1.4 124 ± 8 1.9 >  100 NDl 240 ± 4.1
BNZk 17 ± 0.9 8.2 1.2 ± 0.1 116.3 6.2 ± 0.9 22.4 139 ± 2.3
  1. aEpi Epimastigote, bIC50 Inhibitory concentration 50, cSD Standard deviation, dSI Selectivity index (CC50/IC50), gTryp Trypomastigote, hAmas Amastigote, iCC50 Cytotoxic concentration 50, jCarOx Caryophyllene oxide, kBNZ Benznidazole, lND Not determinated