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Table 4 Relative chemical composition and anti-proliferative effect on T. cruzi of EOs extracted from the Carvone chemotype of L. alba

From: Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide)

Season Material EOa Extrab Time Part Plant Chemical Composition Epif Trypj Amask Vero
minc Limonene % Carvone % Piperd % BCEe % IC50g ± SDh μg/mL SIi IC50g SDh μg/mL SIi IC50g ± SDh μg/mL SIi CC50l ± SDh μg/mL
Dry Fresh B7 30 ALm 19.3 31.5 31.3 2.3 81 ± 2.4 2.5 37 ± 2.1 5.5 >  150 NDo 203 ± 7.5
Rainy Dry 2B8 90 YLn 22.8 5.3 27.5 4.6 96 ± 4.4 1.9 47 ± 3.8 4.0 >  150 ND 186 ± 11.7
Fresh B16 90 AL 30.6 54.5 2.9 97 ± 3.2 2.2 57 ± 3.0 3.8 >  150 ND 216 ± 9.6
Dry B37 30 YL 32.1 54 4 92 ± 3.9 2.1 43 ± 1.8 4.5 >  150 ND 196 ± 18.2
Dry 2B18 45 AL 28 37.8 6.8 86 ± 4.8 1.9 34 ± 3.1 4.9 >  150 ND 165 ± 10.2
Dry 2B19 90 AL 24 34.3 2 78 ± 3.5 2.9 51 ± 1.4 4.4 >  150 ND 226 ± 8.5
  1. aEO Essential oil, bExtra Extraction, cmin Minutes, dPiper Piperitenone, eBCE Bicyclosesquiphellandrene, fEpi Epimastigote, gIC50 Inhibitory concentration 50; hSD Standard deviation, iSI Selectivity index (CC50/IC50), jTryp Trypomastigote, kAmas Amastigote, lCC50 Cytotoxic concentration 50, mAL All leaves, nYL Young leaves, oND Not determined