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Table 3 Relative chemical composition and anti-proliferative effect on T. cruzi of EOs extracted from the Citral chemotype of L. alba

From: Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide)

Season Material EOa Extrab Time Part Plant Chemical Composition Epif Trypj Amask Vero
minc Neral % Geraniol % Geranial % Caryopd % CarOxe % IC50g ± SDh μg/mL SIi IC50g SDh μg/mL SIi IC50g ± SDh μg/mL SIi CC50 l ± SDh μg/mL
Dry Dry A28 45 Inflm 19.3 31.5 31.3 2.3 14 ± 2.6 7.1 31 ± 1.9 3.1 66 ± 4.8 1.5 97 ± 11
Rainy Fresh A25 45 ALn 22.8 5.3 27.5 4.6 2.8 18 ± 0.7 5.3 19.4 ± 0.9 4.9 > 33.3 NDr 95 ± 9.2
Dry A13 30 YLo 30.6 54.5 2.9 17 ± 1.7 7.0 21 ± 1.6 5.7 88 ± 5.4 1.4 121 ± 10.1
A20 30 MLp 32.1 54 4 2.4 9 ± 1.2 7.8 14 ± 0.9 4.7 > 33.3 ND 66 ± 5.9
A23 90 ML 28 37.8 6.8 2.9 8 ± 1.3 6.2 17 ± 1.3 3.0 > 33.3 ND 51 ± 6.2
A24 90 ML 24 34.3 2 5.7 16 ± 1.6 5.7 29 ± 1.8 3.1 69 ± 3.0 1.3 91 ± 7.1
BNZq 17 ± 0.9 8.2 1.2 ± 0.1 116.3 6 ± 0.9 22.4 139 ± 2.3
  1. aEO Essential oil, bExtra Extraction, cmin Minutes, dCaryop Caryophyllene, eCarOx Caryophyllene oxide, fEpi Epimastigote, gIC50 Inhibitory concentration 50, iSD Standard deviation, iSI Selectivity index (CC50/IC50), jTryp Trypomastigote, kAmas Amastigote, lCC50 Cytotoxic concentration 50, mInfl Inflorescences, nAL All leaves, oYL Young leaves, pML Mature leaves, qBNZ Benznidazole, rND Not determined