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Table 2 Summary of findings’ table

From: Yinzhihuang oral liquid combined with phototherapy for neonatal jaundice: a systematic review and meta-analysis of randomized clinical trials

Outcomes Illustrative comparative risks* (95% CI) Relative effect (95% CI) No of Participants (studies) Quality of the evidence (GRADE) Comments
Assumed risk Corresponding risk
Phototherapy Yinzhihuang oral liquid combined with Phototherapy
Total serum bilirubin
serological tests
Follow-up: 0–2 weeks
  The mean total serum bilirubin in the intervention groups was 50.25 μmol/l lower
(64.01 to 36.50 lower)
  1478
(7 studies)

very lowa,b
 
Time tojaundice resolution
Clinical observation
Follow-up: 0–2 weeks
  The mean time to jaundice resolution in the intervention groups was 2.17 days lower
(2.96 to 1.38 lower)
  636
(6 studies)

very lowa,c
 
Failure of jaundice resolution
Clinical observation and serological tests
Follow-up: 0–2 weeks
Study population RR 0.21
(0.14 to 0.32)
1088
(11 studies)

very lowa,d
 
204 per 1000 43 per 1000
(29 to 65)
Medium risk population
200 per 1000 42 per 1000
(28 to 64)
  1. Yinzhihuang oral liquid combined with Phototherapy compared to Phototherapy alone for neonatal jaundice
  2. Patient or population: patients with neonatal jaundice
  3. Intervention: Yinzhihuang oral liquid combined with Phototherapy
  4. Comparison: Phototherapy alone
  5. *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
  6. CI: Confidence interval; RR: Risk ratio
  7. GRADE Working Group grades of evidence
  8. High quality: Further research is very unlikely to change our confidence in the estimate of effect
  9. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
  10. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
  11. Very low quality: We are very uncertain about the estimate
  12. aMost of the included studies were assessed as high risk or unclear risk
  13. bHeterogeneity could be detected with the Value of I squire is 98%
  14. cHeterogeneity could be detected with the Value of I squire is 98%
  15. dClinical heterogeneity might exist for different dosage and baseline characteristics of participants