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Table 1 Characteristics of included trials

From: Yinzhihuang oral liquid combined with phototherapy for neonatal jaundice: a systematic review and meta-analysis of randomized clinical trials

N Study ID Sample(Treatment/Control/Total) diagnostic criteria Intervention Dosage and course duration Control Endpoints
1 Fu KG 2013 [19] 60/60/120 NA Yinzhihuang oral liquid + Phototherapy 3 ml Po Tid Phototherapy:Blue light; 8-12 h/d; 5d Failure of jaundice resolution;
Serious adverse events
2 Huang J 2013 [20] 58/56/114 Practical neonatology Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy:Blue light; 6-8 h/d; 3d Failure of jaundice resolution; Total serum bilirubin
3 Huang N 2004 [21] 32/31/63 NA Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy Span of jaundice resolution;
Serious adverse events
4 Liang LL 2014 [22] 60/60/120 NA Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy:Blue light; 6-8 h/d; 3d Failure of jaundice resolution; Total serum bilirubin
5 Li HF 2013 [23] 30/30/60 Chinese Internal Medicine Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy:Blue light; 16 h/d; 14d Failure of jaundice resolution; Total serum bilirubin;
Time to jaundice resolution;
Serious adverse events
6 Li Q 2013 [24] 54/54/108 NA Yinzhihuang + Phototherapy 3 ml Po Tid Phototherapy:Blue light; 8-12 h/d Time to jaundice resolution; Total serum bilirubin
7 Liu GH 2013 [25] 25/25/50 Practical neonatology Yinzhihuang + Phototherapy NA Phototherapy:Blue light; 6d Failure of jaundice resolution
8 Lu J 2014 [26] 42/42/84 practical paidonosology Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy:Blue light; 10 h/d; 7d Failure of jaundice resolution; Total serum bilirubin;
Time to jaundice resolution
9 Mu J 2015 [27] 43/43/86 Pediatrics Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy:Blue light; 5-7d Failure of jaundice resolution; Total serum bilirubin;
Serious adverse events
10 Qiu J 2014 [28] 60/60/120 Pediatrics Yinzhihuang + Phototherapy 5 ml Po Tid Phototherapy:Blue light; 5d Failure of jaundice resolution; Total serum bilirubin
11 Sun ZY 2013 [29] 100/100/200 Expert Consensus Documents Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy:Blue light; 6 h Bid Total serum bilirubin;
Time to jaundice resolution;
Serious adverse events
12 Wang DF 2014 [30] 100/100/200 NA Yinzhihuang + Phototherapy 5 ml Po Tid Phototherapy:Blue light; 12 h/d; 5d Total serum bilirubin
13 Wu Y 2014 [31] 38/38/76 Practical neonatology Yinzhihuang + Phototherapy 3 ml Po Tid Phototherapy:Blue light; 8-12 h/d; 3-5d Failure of jaundice resolution; Total serum bilirubin;
Time to jaundice resolution;
Serious adverse events
14 Xing XW 2012 [32] 54/54/108 Practical neonatology Yinzhihuang + Phototherapy 3 ml Po Tid Phototherapy:Blue light; 8-12 h/d; 5d Failure of jaundice resolution; Total serum bilirubin;
Time to jaundice resolution;
Serious adverse events
15 Yang ZM 2013 [33] 49/49/98 NA Yinzhihuang + Phototherapy 1 ml/kg Po Tid Phototherapy:Blue light; 5d Time to jaundice resolution;
Serious adverse events
16 Zhao HY 2013 [34] 75/75/150 academic conference recommendation Yinzhihuang + Phototherapy 3 ml Po Tid Phototherapy:Blue light; 12 h/d; 7d Failure of jaundice resolution; Total serum bilirubin
17 Clinical Research Collaborative Group of YZH 2011 [35] 395/409/804 AAP guideline Yinzhihuang + Phototherapy 5 ml Po Bid Phototherapy:Blue light; 8-12 h/d; 7d Total serum bilirubin;
Serious adverse events
  1. Note: NA Not applicable, Po peroral, Tid three times a day, Bid twice a day