Table 1 Characteristics of included trials
N | Study ID | Sample(Treatment/Control/Total) | diagnostic criteria | Intervention | Dosage and course duration | Control | Endpoints |
|---|---|---|---|---|---|---|---|
1 | Fu KG 2013 [19] | 60/60/120 | NA | Yinzhihuang oral liquid + Phototherapy | 3Â ml Po Tid | Phototherapy:Blue light; 8-12Â h/d; 5d | Failure of jaundice resolution; Serious adverse events |
2 | Huang J 2013 [20] | 58/56/114 | Practical neonatology | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy:Blue light; 6-8Â h/d; 3d | Failure of jaundice resolution; Total serum bilirubin |
3 | Huang N 2004 [21] | 32/31/63 | NA | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy | Span of jaundice resolution; Serious adverse events |
4 | Liang LL 2014 [22] | 60/60/120 | NA | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy:Blue light; 6-8Â h/d; 3d | Failure of jaundice resolution; Total serum bilirubin |
5 | Li HF 2013 [23] | 30/30/60 | Chinese Internal Medicine | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy:Blue light; 16Â h/d; 14d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
6 | Li Q 2013 [24] | 54/54/108 | NA | Yinzhihuang + Phototherapy | 3Â ml Po Tid | Phototherapy:Blue light; 8-12Â h/d | Time to jaundice resolution; Total serum bilirubin |
7 | Liu GH 2013 [25] | 25/25/50 | Practical neonatology | Yinzhihuang + Phototherapy | NA | Phototherapy:Blue light; 6d | Failure of jaundice resolution |
8 | Lu J 2014 [26] | 42/42/84 | practical paidonosology | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy:Blue light; 10Â h/d; 7d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution |
9 | Mu J 2015 [27] | 43/43/86 | Pediatrics | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy:Blue light; 5-7d | Failure of jaundice resolution; Total serum bilirubin; Serious adverse events |
10 | Qiu J 2014 [28] | 60/60/120 | Pediatrics | Yinzhihuang + Phototherapy | 5Â ml Po Tid | Phototherapy:Blue light; 5d | Failure of jaundice resolution; Total serum bilirubin |
11 | Sun ZY 2013 [29] | 100/100/200 | Expert Consensus Documents | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy:Blue light; 6Â h Bid | Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
12 | Wang DF 2014 [30] | 100/100/200 | NA | Yinzhihuang + Phototherapy | 5Â ml Po Tid | Phototherapy:Blue light; 12Â h/d; 5d | Total serum bilirubin |
13 | Wu Y 2014 [31] | 38/38/76 | Practical neonatology | Yinzhihuang + Phototherapy | 3Â ml Po Tid | Phototherapy:Blue light; 8-12Â h/d; 3-5d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
14 | Xing XW 2012 [32] | 54/54/108 | Practical neonatology | Yinzhihuang + Phototherapy | 3Â ml Po Tid | Phototherapy:Blue light; 8-12Â h/d; 5d | Failure of jaundice resolution; Total serum bilirubin; Time to jaundice resolution; Serious adverse events |
15 | Yang ZM 2013 [33] | 49/49/98 | NA | Yinzhihuang + Phototherapy | 1Â ml/kg Po Tid | Phototherapy:Blue light; 5d | Time to jaundice resolution; Serious adverse events |
16 | Zhao HY 2013 [34] | 75/75/150 | academic conference recommendation | Yinzhihuang + Phototherapy | 3Â ml Po Tid | Phototherapy:Blue light; 12Â h/d; 7d | Failure of jaundice resolution; Total serum bilirubin |
17 | Clinical Research Collaborative Group of YZH 2011 [35] | 395/409/804 | AAP guideline | Yinzhihuang + Phototherapy | 5Â ml Po Bid | Phototherapy:Blue light; 8-12Â h/d; 7d | Total serum bilirubin; Serious adverse events |