Fig. 4

Trial sequential analysis of total serum bilirubin for Yinzhihuang oral liquid combined with phototherapy versus phototherapy monotherapy. Note: Trial sequential analysis illustrated that the cumulative Z-curve (blue curve) had crossed the monitoring boundaries (red inward sloping curves) and reached the diversity-adjusted required information size (DARIS), which is calculated to be 1301 patients (vertical line) based on a mean difference (MD) of -30umol/L, variance of 530.19, type I error of 5% and type II error of 20%.) of 20%, and diversity (D) of 30%