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Table 3 Effects of TAU-CL, AZA, and their combination on the percentage of DNA fragmentation, Caspase 9 activity, and Bcl-2 expression in different groups

From: Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection

Groups Group I
(Control)
Group II
(TAU-CL)
Group III
(AZA)
Group IV
(TAU-CL/AZA)
Parameters
DNA fragmentation (%) 68.2 ± 5.01 70.55± 6 91.59a ± 10.59 68.19b ± 4.8
Caspase-9 activity
(ng/g tissue)
1.6 ± 0.15 1.7 ± 0.07 2.5a ± 0.13 1.6b ± 0.17
BCL2
(ng/mg tissue)
1.25 ± 0.02 1.3 ± 0.08 0.75a ± 0.05 1.2b ± 0.13
  1. The percentage of DNA fragmentation, Caspase 9 activity, and Bcl-2 expression, measured by western blot, β-actin was used as a loading control (C), in different groups
  2. Data are expressed as the mean ± SEM, and data were analyzed using one-way ANOVA followed by the Bonferroni post hoc multiple comparison test (n = 10). Difference between groups were considered statistically significant at P ≤ 0.05. (a) Significant values versus the group control, (b) Significant values versus the AZA group