Oedema | |||||||||
---|---|---|---|---|---|---|---|---|---|
Drug (mg/kg b.wt. P.O) | Zero time (cm) | 1Â h (cm) (% increase) | % of Inhibition | 2Â h (cm) (% increase) | % of Inhibition | 3Â h (cm) (% increase) | % of Inhibition | 4Â h (cm) (% increase) | % of Inhibition |
Saline | 0.37 ± 0.01 | 0.49 ± 0.01 | – | 0.56 ± 0.03 | – | 0.57 ± 0.009 | – | 0.52 ± 0.02 | – |
 |  | (32.43 ± 0.3) |  | (51.35 ± 0.54)* |  | (54.05 ± 0.63)* |  | (40.54 ± 0.6) |  |
Indomethain | 0.36 ±0.01 | 0.48 ± 0.02 | 2.68 | 0.45 ± 0.02 | 51.31 | 0.44 ± 0.006 | 58.88 | 0.4 ± 0.01 | 72.59 |
(25) |  | (33.3 ± 0.21)* |  | (25 ± 0.25)* |  | (22.22 ± 0.22)* |  | (11.11 ± 0.38)* |  |
AME | |||||||||
(125) | 0.37 ± 0.01 | 0.47 ± 0.007 | 16.65 | 0.48 ± 0.02 | 42.10 | 0.48 ± 0.02 | 45.01 | 0.48 ± 0.02 | 26.68 |
 |  | (27.03 ± 0.24)*# |  | (29.73 ± 0. 5)*# |  | (29.73 ± 0.54)*# |  | (29.73 ± 0.49)*@# |  |
(250) | 0.4 ± 0.006 | 0.56 ± 0.03 | 23.34 | 0.45 ± 0.02 | 75.66 | 0.45 ± 0.02 | 76.87 | 0.48 ± 0.04 | 50.66 |
 |  | (40 ± 1.9) # |  | (12.5 ± 0.62)* |  | (12.5 ± 0.23)* |  | (20 ± 0.29)* # |  |
(500) | 0.4 ± 0.002 | 0.45 ± 0.01 | 61.46 | 0.44 ± 0.01 | 80.53 | 0.43 ± 0.02 | 86.12 | 0.41 ± 0.02 | 93.83 |
 |  | (12.5 ± 3.4)*@ |  | (10 ± 0.32)*@ |  | (7.5 ± 0.33)*@ |  | (2.5 ± 0.16)* |  |