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Table 3 Anti-inflammatory activity of P. racemosa leaves AME and indomethacin on carrageenan-induced paw oedema in rats

From: Phenolic profile, anti-inflammatory, antinociceptive, anti-ulcerogenic and hepatoprotective activities of Pimenta racemosa leaves

Oedema

Drug (mg/kg b.wt. P.O)

Zero time (cm)

1 h (cm) (% increase)

% of Inhibition

2 h (cm) (% increase)

% of Inhibition

3 h (cm) (% increase)

% of Inhibition

4 h (cm) (% increase)

% of Inhibition

Saline

0.37 ± 0.01

0.49 ± 0.01

–

0.56 ± 0.03

–

0.57 ± 0.009

–

0.52 ± 0.02

–

  

(32.43 ± 0.3)

 

(51.35 ± 0.54)*

 

(54.05 ± 0.63)*

 

(40.54 ± 0.6)

 

Indomethain

0.36 ±0.01

0.48 ± 0.02

2.68

0.45 ± 0.02

51.31

0.44 ± 0.006

58.88

0.4 ± 0.01

72.59

(25)

 

(33.3 ± 0.21)*

 

(25 ± 0.25)*

 

(22.22 ± 0.22)*

 

(11.11 ± 0.38)*

 

AME

(125)

0.37 ± 0.01

0.47 ± 0.007

16.65

0.48 ± 0.02

42.10

0.48 ± 0.02

45.01

0.48 ± 0.02

26.68

  

(27.03 ± 0.24)*#

 

(29.73 ± 0. 5)*#

 

(29.73 ± 0.54)*#

 

(29.73 ± 0.49)*@#

 

(250)

0.4 ± 0.006

0.56 ± 0.03

23.34

0.45 ± 0.02

75.66

0.45 ± 0.02

76.87

0.48 ± 0.04

50.66

  

(40 ± 1.9) #

 

(12.5 ± 0.62)*

 

(12.5 ± 0.23)*

 

(20 ± 0.29)* #

 

(500)

0.4 ± 0.002

0.45 ± 0.01

61.46

0.44 ± 0.01

80.53

0.43 ± 0.02

86.12

0.41 ± 0.02

93.83

  

(12.5 ± 3.4)*@

 

(10 ± 0.32)*@

 

(7.5 ± 0.33)*@

 

(2.5 ± 0.16)*

 
  1. Results are expressed as means % of inhibition ± SE; n = 8; P ≤ 0.05; % of increase of inflammation was measured relative to zero time of each group; % of inhibition of inflammation measured at the same time interval for each group)
  2. *Significant difference from saline control group at P ≤ 0.05; @ Significant different from indomethacin group at P ≤ 0.05; # Significant different from AME 500 mg/kg b.wt. group at P ≤ 0 .05