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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties

Fig. 5

The effects of Zyflamend on phosphorylation of LKB1 (at Ser428) and AMPKα (at Thr172) following inhibition with radicicol and knockdown of LKB1 in CWR22Rv1 cells. A Western blot of pLKB1 ± Zyflamend (200 μg/mL, 30 min – 3 h). B, C Western blot of pAMPKα following treatment with radicicol (5 μM, 24 h) ± Zyflamend (200 μg/mL, 30 min). D-F Western blot of pAMPKα and pACC (at Ser79) following knockdown of LKB1 ± Zyflamend (200 μg/mL, 30 min). Data are presented as mean ± SEM, n = 3. Bars with different letters are statistically different at p < 0.05. Abbreviations: CON, Control; Rad, Radicicol; Zyf, Zyflamend

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