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Table 2 Levels of cytokines/chemokines in culture medium of pAECs stimulated with LPS (10 μg/ml) in the presence or absence of Cucumis sativus L. extract (CSE 2 mg/ml). Data shown are representative of at least three independent experiments and represent the mean ± SEM. Significant differences are indicated by (p < 0.05) *, and (p < 0.001) by ** nd not detectable

From: Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells

ng/ml

1 h

7 h

24 h

CSE-/LPS+

CSE+/LPS+

CSE-/LPS+

CSE+/LPS+

CSE-/LPS+

CSE+/LPS+

IL-1α

nd

nd

nd

nd

0.0592 ± 0.0019

0.0140 ± 00002**

IL-6

nd

0.1574 ± 0.0064

4.3163 ± 0.0893

3.3889 ± 0.0835*

8.0129 ± 0.3067

3.9270 ± 0.0335**

IL-8

6.3445 ± 0.4821

2.3809 ± 0.0434**

> 50

24.2300 ± 2.2100

31.5600 ± 3.8210*

25.1500 ± 2.7210

IL-10

0.0077 ± 0.0023

0.0355 ± 0.0010**

0.0187 ± 0.0025

0.0395 ± 0.0034*

0.0209 ± 00017

0.0400 ± 0.0056**

IL-18

0.0319 ± 0.0021

0.1796 ± 0.0049**

0.0572 ± 0.0011

0.1897 ± 0.0033**

0.0606 ± 0.0034

0.1913 ± 0.0056**

GM-CSF

0.1083 ± 0.0071

nd

0.1895 ± 0.0221

nd

0.2061 ± 0.0094

0.0021 ± 0.0037**

IFN-γ

0.0501 ± 0.0436

1.5529 ± 0.0292**

0.2654 ± 0.0889

0.5230 ± 0.0725*

0.0725 ± 0.0378

0.3522 ± 0.0340**