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Table 2 Selectivity of the cytotoxicity of anthraquinone derivatives (compound 1–5) to various cancer cells as compared with MDCK cells

From: Cytotoxic properties of the anthraquinone derivatives isolated from the roots of Rubia philippinensis

Compounds IC50 (μM)a
SK-MEL-5 B16F10 MCF7 MDA-MB-231
1 2.11 3.95 2.94 3.89
2 3.61 2.17 2.11 2.85
3 3.76 2.02 4.05 4.10
4 3.18 2.86 4.31 4.63
5 1.85 2.68 3.28 6.06
  1. aThe selectivity index is the ratio of the IC50 values of the treatments on MDCK cells to those in the cancer cell lines. SK-MEL-5 (human melanoma); B16F10 (murine melanoma); MCF-7 (human breast adenocarcinoma); MDA-MB-231 (human breast adenocarcinoma)