Fig. 4

HT improves synaptic function in APP/PS1 Transgenic Mice. Electrophysiological determination of deficits in Schaffer collateral-CA1 synaptic transmission and the induction of long-term potentiation. a A plot showing input/output (I/O) curves in response to stimulus (0.1–1.1 mA) at the hippocampal CA1 region of APP/PS1 control mice, APP/PS1 mice receiving HT, and APP/PS1 mice receiving MEM treatment (6 months old). The I/O curve was measured by averaging the slope of EPSPs against stimulus intensity at 0.1–1.1 mA. The slope of the regression line for the I/O curve in APP/PS1 mice was markedly reduced. With HT or MEM treatment, the reduction in the I/O curve slope was significantly improved in APP/PS1 mice. All values are expressed as the mean ± SEM from 6 mice in each group. #P < 0.05 HT group versus APP/PS1 control mice, ##P < 0.01 MEM group versus APP/PS1 control mice. b The capacity to establish long-term potentiation (LTP) from high-frequency stimulus (HFS, 100 pulses at 100 Hz) with the same pre-HFS intensity at hippocampal CA1 region of APP/PS1 control mice. APP/PS1 mice with HT treatment and APP/PS1 mice with MEM treatment