Table 2 Mean (CI 95%) and analysis of variance (ANOVA) of baseline, Patient-Reported Outcomes

 Tension/Anxiety

9.85 (7.39–12.30)

7.00 (3.87–10.12)

2.25 (0.14)

 Depression/Dejection

12.90 (7.51–18.28)

9.10 (4.44–13.75)

1.24 (0.27)

 Anger/Hostility

9.50 (5.98–13.01)

8.65 (4.67–12.62)

0.11 (0.73)

 Vigor/Activity

24.40 (20.23–28.56)

28.75 (25.34–32.15)

2.86 (0.09)

 Fatigue/Inertia

11.75 (9.51–13.98)

9.20 (7.26–11.13)

3.25 (0.07)

 Confusion/Bewilderment

8.60 (5.37–11.82)

6.55 (2.91–10.18)

0.77 (0.38)

 TMD

128.20 (113.47–142.93)

111.75 (96.55–126.95)

2.64 (0.11)

 Global health status/QoL

53.74 (41.84–65.64)

57.08 (46.77–67.38)

0.19 (0.66)

 Physical functioning

67.61 (56.17–79.04)

76.91 (67.47–86.35)

1.72 (0.19)

 Role functioning

75.83 (60.75–90.90)

79.16 (64.87–93.45)

0.11 (0.73)

 Emotional functioning

72.56 (59.55–85,57)

79.68 (69.72–89.63)

0.82 (0.36)

 Cognitive functioning

81.66 (69.29–94.03)

79.99 (67.96–92.02)

0.04 (0.84)

 Social functioning

79.99 (64.68–95.30)

90.83 (83.04–98.62)

1.74 (0.19)

 Fatigue

51.07 (40.48–61.65)

40.53 (30.50–50.56)

2.28 (0.13)

 Nausea and vomiting

0.87 (0.96–2.71)

1.66 (0.73–4.06)

0.29 (0.59)

 Pain

50.83 (38.31–63.35)

38.33 (27.27–49.39)

2.45 (0.12)

 Dyspnoea

6.66 (−4.18–17.52)

8.33 (−2.84–19.50)

0.05 (0.82)

 Insomnia

53.33 (37.00–69.65)

44.99 (25.87–64.12)

0.48 (0.49)

 Appetite loss

14.99 (2.12–27.87)

14.99 (3.15–26.84)

0.00 (1.00)

 Constipation

4.99 (−2.63–12.63)

8.33 (−1.63–18.29)

0.30 (0.58)

 Diarrhoea

11.66 (0.04–23.28)

6.66 (−2.93–16.28)

0.48 (0.49)

 Financial difficulties

8.33 (−3.93–20.60)

14.99 (2.12–27.87)

0.61 (0.43)

 VAS

7.40 (6.82–7.98)

6.65 (5.98–7.32)

3.17 (0.08)

 SFI

57.40 (49.59–65.20)

56.90 (47.66–66.13)

0.007 (0.93)

 ULFI

61.80 (53.93–69.66)

69.60 (62.07–77.12)

2.25 (0.14)

 BAI

0.59 (0.47–0.71)

0.42 (0.28–0.55)

4.07 (0.05)

 MBS

0.40 (0.23–0.56)

0.33 (0.21–0.44)

0.53 (0.46)

 BADIX

0.53 (0.41–0.65)

0.40 (0.28–0.51)

2.93 (0.09)