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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism

Fig. 7

A novel mechanism underlying the antitumor activities of HHT. Homoharringtonine regulates the alternative splicing of Bcl-x and Caspase 9 through a PP1-dependent mechanism, resulting in a decreased expression of anti-apoptotic Bcl-xL and Caspase 9b with a concomitant increase in the levels of pro-apoptotic Bcl-xS and Caspase 9a in various cancer cells

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