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Table 4 Hematological parameters of male rats in chronic toxicity test

From: Acute and chronic toxicity of a polyherbal preparation – Jueyin granules

Treaments

Time

Control

JYG-H

JYG-M

JYG-L

7.5 g/kg

3.75 g/kg

1.875 g/kg

WBC

3 month

5.00 ± 1.01

8.27 ± 3.50

5.82 ± 1.28

6.81 ± 1.10

(× 109/L)

6 month

6.23 ± 2.20

6.06 ± 3.20

5.55 ± 1.23

5.52 ± 1.64

 

1 month recovery

2.44 ± 1.30

2.36 ± 1.05

2.78 ± 0.85

2.33 ± 1.21

RBC

3 month

8.42 ± 0.67

8.06 ± 0.23

8.37 ± 0.16

8.58 ± 0.21

(× 1012/L)

6 month

8.80 ± 0.43

8.16 ± 0.51*

8.33 ± 0.47*

8.70 ± 0.39

 

1 month recovery

7.05 ± 0.65

7.92 ± 0.76

7.57 ± 0.53

7.06 ± 0.79

HGB

3 month

14.56 ± 0.68

14.76 ± 0.36

15.02 ± 0.23

15.06 ± 0.42

(g/L)

6 month

15.14 ± 0.37

14.51 ± 0.78

14.72 ± 0.76

15.21 ± 0.49

 

1 month recovery

13.26 ± 1.14

15.10 ± 1.01*

14.18 ± 1.09

13.14 ± 1.38

PLT

3 month

1214 ± 164

1108 ± 132

1080 ± 79

1186 ± 83

(× 109/L)

6 month

1134 ± 172

1182 ± 202

1102 ± 213

1210 ± 114

 

1 month recovery

855 ± 314

897 ± 185

814 ± 238

759 ± 399

NEUT

3 month

1.53 ± 0.65

2.61 ± 1.69

1.51 ± 0.76

1.91 ± 0.70

(× 109/L)

6 month

1.61 ± 0.56

2.01 ± 1.13

1.71 ± 0.47

1.65 ± 0.81

 

1 month recovery

0.74 ± 0.31

0.67 ± 0.20

0.93 ± 0.08

1.09 ± 0.86

LYMPH

3 month

2.91 ± 1.42

4.89 ± 1.89

3.78 ± 1.88

4.16 ± 0.62

(×109/L)

6 month

3.84 ± 1.55

3.34 ± 1.86

3.27 ± 0.97

3.36 ± 1.48

 

1 month recovery

1.43 ± 0.91

1.39 ± 0.71

1.50 ± 0.71

0.99 ± 0.42

MONO

3 month

0.40 ± 0.24

0.58 ± 0.20

0.38 ± 0.17

0.53 ± 0.16

(×109/L)

6 month

0.49 ± 0.33

0.32 ± 0.24

0.29 ± 0.14

0.26 ± 0.15*

 

1 month recovery

0.12 ± 0.07

0.19 ± 0.15

0.24 ± 0.11

0.15 ± 0.09

  1. JYG-H, JYG-M, JYG-L Jueyin granules high-dose, medium dose, low-dose group, respectively, WBC total white blood cell count, RBC red blood cell, HGB hemoglobin, PLT blood platelet, Neut neutrophil, Lymph lymphocyte, Mono mononucleosis. The values are expressed as mean ± SEM (n = 10 rats for 3 months; n = 17–19 rats for 6 months; n = 10 rats for 1 month recovery). *Significantly different from control group (p < 0.05)