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Table 3 Synergistic potential of solamargine and the aqueous alkaloid-enriched fraction as described by their FIX values in a panel of cancerous and non-cancerous cell lines

From: Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition

Cell type Cancerous Non-cancerous
Cell line SH-SY5Y SK-Br3 C2C12 EA.hy926
Compound/Fraction Solamargine Aqueous alkaloid-enriched fraction Solamargine Aqueous alkaloid-enriched fraction Solamargine Aqueous alkaloid-enriched fraction Solamargine Aqueous alkaloid-enriched fraction
IC50 of (A) [IC50 sample + doxorubicin (μM or μg/mL)] 3.4 7.39 4.3 11.18 30.77 15.7 5.5 2.62
IC50 of (B) [IC50 doxorubicin + sample (nM)] 16.27 24.22 40.83 47.48 149.9 140.7 213.4 220
IC50 (A) [Solamargine (μM) or aqueous alone (μg/mL)] 15.62 26.5 18.59 19.7 20.25 13.7 8.3 7.3
IC50 (B) [doxorubicin alone (nM)] 56.6 56.6 94.1 94.1 148.5 148.5 381.6 381.6
FIC (A) 0.22 0.28 0.23 0.57 1.52 1.15 0.66 0.36
FIC (B) 0.29 0.43 0.43 0.5 1.01 0.95 0.56 0.58
FIX value 0.51 0.71 0.66 1.07 2.53 2.1 1.22 0.94
Result Additive effect Additive effect Additive effect Indifferent effect Antagonistic effect Antagonistic effect Indifferent effect Additive effect