Fig. 4From: Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-κB and mitogen-activated protein kinase pathwaysRPR-induced bone resorption activity for osteoclasts. a Human PBMCs or murine RAW264.7 macrophages were placed on a synthetic bone cell culture and then treated with RANKL and M-CSF or RPR. After 7 or 14 days of culture, cells were separated. Microscopy was used to determine the number of pits in each well, which were photographed. b Data are the mean ± SD from three independent tests; *p < 0.01, **p < 0.001, compared with the medium as the singular controlBack to article page