Fig. 1From: Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-κB and mitogen-activated protein kinase pathwaysRPR-induced osteoclast-like multi-nucleated cells from RAW264.7 macrophages and human monocytes. a RAW264.7 cells and (b) human PBMCs were cultured with RANKL+M-CSF or RPR, and then TRAP-stained. c RAW264.7 cells and (d) human PBMCs were cultured with RANKL+M-CSF or increasing concentrations of RPR, and then TRAP-stained. Data represent the mean ± SD of 3–6 individual experiments. *p < 0.01; **p < 0.001, compared with the controlBack to article page