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Table 5 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS-stimulated and 72 h WRE-treated THP-1 cells

From: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

WRE (mg/ml) Caspase-8 (RLU ×  105) Caspase-9 (RLU ×  105) Caspase-3/7 (RLU ×  105) ATP (RLU ×  105)
Control 0.991 ± 0.0001 5.738 ± 0.002 7.463 ± 0.012 4.332 ± 0.002
0.05 0.978 ± 0.0001 *** 5.562 ± 0.009 *** 6.919 ± 0.003 *** 4.133 ± 0.005 ***
0.1 1.216 ± 0.001 *** 7.045 ± 0.005 *** 8.211 ± 0.002 *** 4.889 ± 0.005 ***
0.2 1.095 ± 0.001 *** 6.091 ± 0.001 *** 7.532 ± 0.006 *** 4.576 ± 0.004 ***
0.4 0.952 ± 0.0003 *** 5.639 ± 0.003 *** 6.626 ± 0.007 *** 4.039 ± 0.0003 ***
  1. (Values expressed as mean ± SD, *** p < 0.0001 compared to the control)