Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

Table 5 Modulation of caspase (-8, -9, -3/7) activity and ATP levels in LPS-stimulated and 72 h W_RE-treated THP-1 cells

W_RE (mg/ml)	Caspase-8 (RLU × 10⁵)	Caspase-9 (RLU × 10⁵)	Caspase-3/7 (RLU × 10⁵)	ATP (RLU × 10⁵)
Control	0.991 ± 0.0001	5.738 ± 0.002	7.463 ± 0.012	4.332 ± 0.002
0.05	0.978 ± 0.0001 ^***	5.562 ± 0.009 ^***	6.919 ± 0.003 ^***	4.133 ± 0.005 ^***
0.1	1.216 ± 0.001 ^***	7.045 ± 0.005 ^***	8.211 ± 0.002 ^***	4.889 ± 0.005 ^***
0.2	1.095 ± 0.001 ^***	6.091 ± 0.001 ^***	7.532 ± 0.006 ^***	4.576 ± 0.004 ^***
0.4	0.952 ± 0.0003 ^***	5.639 ± 0.003 ^***	6.626 ± 0.007 ^***	4.039 ± 0.0003 ^***

ISSN: 2662-7671