Skip to main content

Table 1 The effect of AGME on MDA level, % inhibition of O2−, GPx activity, and MAO-A,B activities of cerebral cortex and striatum areas of mice after MPTP treatment

From: The antioxidant and neurochemical activity of Apium graveolens L. and its ameliorative effect on MPTP-induced Parkinson-like symptoms in mice

Groups

MDA (μmol/mg protein)

% inhibition of O2-

GPx activity (Unit/g protein)

MAO-A activity (μmol/min.g tissue)

MAO-B activity (μmol/min.g tissue)

cortex

striatum

cortex

striatum

cortex

striatum

cortex

striatum

cortex

striatum

Control

2.22 ± 0.26

1.53 ± 0.56

16.48 ± 2.14

19.87 ± 1.99

18.45 ± 1.70

20.87 ± 1.68

3.00 ± 1.01

2.73 ± 1.05

5.01 ± 1.01

4.73 ± 1.05

Vehicle+MPTP

6.34 ± 0.41a

5.96 ± 0.22a

5.16 ± 1.46a

8.32 ± 1.10a

5.09 ± 2.27a

6.54 ± 2.04a

9.02 ± 1.00a

10.13 ± 1.18a

15.00 ± 1.04a

17.13 ± 1.18a

Tidomet plus 25 + MPTP

2.81 ± 0.48b

1.70 ± 0.13b

13.08 ± 1.95b

11.87 ± 2.03b

15.92 ± 0.81b

13.41 ± 1.61b

5.46 ± 0.67b

6.16 ± 1.25a

10.46 ± 0.67b

8.16 ± 1.25b

AGME 125 + MPTP

2.93 ± 0.41

4.77 ± 0.15

10.85 ± 1.55

9.98 ± 2.55

6.19 ± 1.81

7.83 ± 0.93

8.51 ± 1.19

9.56 ± 1.34

11.51 ± 1.19

10.56 ± 1.34

AGME 250 + MPTP

2.12 ± 0.43b

3.75 ± 0.12b

12.05 ± 1.99b

14.04 ± 2.26b

10.55 ± 1.18b

12.37 ± 1.15b

5.86 ± 0.68b

6.70 ± 0.57 b

10.86 ± 0.68b

8.70 ± 0.57b

AGME 375 + MPTP

2.01 ± 0.35b

0.17 ± 0.19 b

15.75 ± 1.13b

18.14 ± 1.26b,c

16.54 ± 1.16b

18.71 ± 1.26b,c

4.21 ± 0.52b

3.42 ± 0.72b,c

6.21 ± 0.53b,c

4.42 ± 0.72b,c

  1. Data were represented as mean ± S.D. of three replicates, n = 8 each, a vs. control group, p < 0.01; b vs. vehicle+MPTP-treated group, p < 0.05; c vs.Tidomet plus 25 + MPTP-treated group, p < 0.05