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Table 4 Mutagenicity testing of the pure compounds against the four S. typhimurium tester strains

From: The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds

Compound *conc. (%) TA97a TA98 TA100 TA102
(-S9) (+S9) (-S9) (+S9) (-S9) (+S9) (-S9) (+S9)
L-arginine 1 214 ± 3 204 ± 2 64 ± 3 68 ± 1 85 ± 3 87 ± 2 255 ± 3 263 ± 1
2.5 167 ± 2 146 ± 2 64 ± 3 66 ± 3 72 ± 1 73 ± 4 236 ± 3 226 ± 2
5 125 ± 2 113 ± 2 65 ± 4 60 ± 2 62 ± 2 68 ± 1 217 ± 3 206 ± 4
Spon. Revertants   223 ± 2 105 ± 3 37 ± 3 44 ± 3 105 ± 4 105 ± 2 293 ± 5 365 ± 3
L-canavanine 1 184 ± 3 187 ± 4 36 ± 2 102 ± 3 216 ± 4 284 ± 4 189 ± 5 294 ± 3
2.5 155 ± 4 158 ± 3 34 ± 3 81 ± 3 182 ± 3 222 ± 3 168 ± 4 254 ± 3
5 130 ± 4 145 ± 3 34 ± 3 59 ± 2 120 ± 3 201 ± 3 154 ± 4 189 ± 2
Spon. Revertants   196 ± 3 215 ± 4 51 ± 3 28 ± 2 204 ± 4 204 ± 4 270 ± 6 327 ± 4
D-pinitol 1 245 ± 4 200 ± 1 41 ± 3 97 ± 3 289 ± 5 312 ± 2 414 ± 2 460 ± 5
2.5 205 ± 3 173 ± 2 42 ± 4 72 ± 2 275 ± 6 288 ± 6 395 ± 3 465 ± 3
5 186 ± 4 158 ± 5 42 ± 2 54 ± 1 241 ± 4 267 ± 4 386 ± 4 467 ± 1
Spon. Revertants   173 ± 3 184 ± 3 42 ± 3 50 ± 1 204 ± 2 204 ± 2 378 ± 2 526 ± 4
GABA 1 230 ± 4 152 ± 8 24 ± 1 117 ± 3 233 ± 4 286 ± 3 188 ± 3 385 ± 4
2.5 175 ± 4 134 ± 3 25 ± 3 87 ± 2 195 ± 4 288 ± 7 175 ± 3 318 ± 4
5 128 ± 6 138 ± 6 24 ± 1 61 ± 3 141 ± 2 288 ± 3 162 ± 3 290 ± 2
Spon. Revertants   196 ± 3 215 ± 4 28 ± 2 51 ± 3 204 ± 4 204 ± 4 270 ± 6 327 ± 4
Common Valid Range [39]   75-200 100-200 20-50 20-50 75-200 75-200 100-300 200-400
  1. Activity expressed as mean revertant counts ± STD. *Where revertant counts are more than three times that of spontaneous revertants, the compound is considered to be mutagenic [39]