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Table 2 Mutagenicity testing of sutherlandia extracts against four S. typhimurium tester strains

From: The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds

Extract

*conc. (%)

TA97a

TA98

TA100

TA102

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

MeOH

10

214 ± 3

237 ± 4

63 ± 3

69 ± 1

171 ± 3

184 ± 4

314 ± 61

387 ± 47

50

191 ± 5

203 ± 3

77 ± 3

92 ± 5

117 ± 4

132 ± 5

264 ± 48

365 ± 9

EA

5

216 ± 3

271 ± 7

45 ± 3

53 ± 3

204 ± 3

221 ± 4

209 ± 21

297 ± 22

20

191 ± 5

202 ± 2

63 ± 1

69 ± 1

174 ± 3

184 ± 3

210 ± 34

288 ± 25

Spontaneous revertants

185 ± 3

138 ± 5

31 ± 2

44 ± 3

102 ± 4

119 ± 2

185 ± 32

216 ± 41

Common Valid Range [39]

75-200

100-200

20-50

20-50

75-200

75-200

100-300

200-400

Revertant counts

(Positive#control)

369 ± 5

(9-AA)

256 ± 6

(2-AAF)

373 ± 5

(AFB1)

997 ± 99

(CHP)

  1. Activity expressed as mean revertant counts ± STD (n = 5). * For TA97a concentration was 0.5 and 2.5% for both extracts. #See details in Table 1 above. Where revertant counts are more than three times that of spontaneous revertant count, the compound is considered to be mutagenic [39]
  2. Abbreviations: 9-AA 9-aminoacradine, 2-AAF 2-acetamidofluorene, AFB 1 aflatoxin B1, CHP cumoyl hydroperoxide