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Table 2 Mutagenicity testing of sutherlandia extracts against four S. typhimurium tester strains

From: The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds

Extract *conc. (%) TA97a TA98 TA100 TA102
(-S9) (+S9) (-S9) (+S9) (-S9) (+S9) (-S9) (+S9)
MeOH 10 214 ± 3 237 ± 4 63 ± 3 69 ± 1 171 ± 3 184 ± 4 314 ± 61 387 ± 47
50 191 ± 5 203 ± 3 77 ± 3 92 ± 5 117 ± 4 132 ± 5 264 ± 48 365 ± 9
EA 5 216 ± 3 271 ± 7 45 ± 3 53 ± 3 204 ± 3 221 ± 4 209 ± 21 297 ± 22
20 191 ± 5 202 ± 2 63 ± 1 69 ± 1 174 ± 3 184 ± 3 210 ± 34 288 ± 25
Spontaneous revertants 185 ± 3 138 ± 5 31 ± 2 44 ± 3 102 ± 4 119 ± 2 185 ± 32 216 ± 41
Common Valid Range [39] 75-200 100-200 20-50 20-50 75-200 75-200 100-300 200-400
Revertant counts
(Positive#control)
369 ± 5
(9-AA)
256 ± 6
(2-AAF)
373 ± 5
(AFB1)
997 ± 99
(CHP)
  1. Activity expressed as mean revertant counts ± STD (n = 5). * For TA97a concentration was 0.5 and 2.5% for both extracts. #See details in Table 1 above. Where revertant counts are more than three times that of spontaneous revertant count, the compound is considered to be mutagenic [39]
  2. Abbreviations: 9-AA 9-aminoacradine, 2-AAF 2-acetamidofluorene, AFB 1 aflatoxin B1, CHP cumoyl hydroperoxide