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Table 1 Antimutagenicity of the sutherlandia extracts on the four S. typhimurium tester strains. Inhibition expressed as % inhibition ± STD

From: The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds

Extract

Conc./plate (%)

TA97a

(-S9)*

TA98

(+S9)

TA100

(+S9)

TA102

(-S9)

MeOH

50

18.4 ± 1.6c

(−) 48.9 ± 12.7c#

(−) 16.2 ± 5.6c#

72.0 ± 15.1c

25

38.1 ± 6.3b

17.0 ± 3.6b

68.1 ± 3.7b

97.2 ± 1.4b

10

85.4 ± 3.7a

91.4 ± 1.6a

83.2 ± 5.8a

114.5 ± 3.1a

EA

20

26.0 ± 3.3c

41.8 ± 2.5c

57.2 ± 5.8c

98.6 ± 3.9c

10

64.8 ± 4.9b

69.7 ± 2.8b

75.5 ± 4.2b

109.0 ± 4.7b

5

90.2 ± 3.2a

91.8 ± 3.7a

95.6 ± 3.9a

127.3 ± 10.4a

Diagnostic mutagen

9-AA

(0.02 μg/plate)

2-AAF

(5 μg/plate)

AFB1

(40 μg/plate)

CHP

(0.1 μg/plate)

Revertant counts

369 ± 5

256 ± 6

373 ± 5

997 ± 99

  1. *For TA97a concentration is 0.5, 1 and 2.5% for both extracts. The means of % inhibition of the three dilutions were compared for both extracts to determine significant differences between them. Mean % inhibitions followed with different letters indicate significant difference between them at P ≤ 0.01. Means followed by the same letters indicated no significant difference at P ≤ 0.01# pro-mutagenicity of the 10% solution of the aqueous methanol extract
  2. Abbreviations: Conc concentration, MeOH aqueous methanol extract, EA ethylacetate extract, 9-AA 9-aminoacradine, 2-AAF 2-acetamidofluorene, AFB 1 aflatoxin B1, CHP cumoyl hydroperoxide