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Table 1 Antimutagenicity of the sutherlandia extracts on the four S. typhimurium tester strains. Inhibition expressed as % inhibition ± STD

From: The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds

Extract Conc./plate (%) TA97a
(-S9)*
TA98
(+S9)
TA100
(+S9)
TA102
(-S9)
MeOH 50 18.4 ± 1.6c (−) 48.9 ± 12.7c# (−) 16.2 ± 5.6c# 72.0 ± 15.1c
25 38.1 ± 6.3b 17.0 ± 3.6b 68.1 ± 3.7b 97.2 ± 1.4b
10 85.4 ± 3.7a 91.4 ± 1.6a 83.2 ± 5.8a 114.5 ± 3.1a
EA 20 26.0 ± 3.3c 41.8 ± 2.5c 57.2 ± 5.8c 98.6 ± 3.9c
10 64.8 ± 4.9b 69.7 ± 2.8b 75.5 ± 4.2b 109.0 ± 4.7b
5 90.2 ± 3.2a 91.8 ± 3.7a 95.6 ± 3.9a 127.3 ± 10.4a
Diagnostic mutagen 9-AA
(0.02 μg/plate)
2-AAF
(5 μg/plate)
AFB1
(40 μg/plate)
CHP
(0.1 μg/plate)
Revertant counts 369 ± 5 256 ± 6 373 ± 5 997 ± 99
  1. *For TA97a concentration is 0.5, 1 and 2.5% for both extracts. The means of % inhibition of the three dilutions were compared for both extracts to determine significant differences between them. Mean % inhibitions followed with different letters indicate significant difference between them at P ≤ 0.01. Means followed by the same letters indicated no significant difference at P ≤ 0.01# pro-mutagenicity of the 10% solution of the aqueous methanol extract
  2. Abbreviations: Conc concentration, MeOH aqueous methanol extract, EA ethylacetate extract, 9-AA 9-aminoacradine, 2-AAF 2-acetamidofluorene, AFB 1 aflatoxin B1, CHP cumoyl hydroperoxide