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Table 3 Inhibitory effect of indomethacin on plasma electrolyte level induced by EFPA in rats

From: The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

Groups Plasma levels (mEq/L)
Na+ Cl K+ Ca2+
Control 114.70 ± 5.51 104.33 ± 3.90 70.50 ± 2.90 5.40 ± 2.52
EFPA (10 mg/kg) 125.50 ± 4.00 102.00 ± 4.32 54.70 ± 2.80* 5.21 ± 2.60
EFPA (10 mg/kg) + Indomethacin (5 mg/kg) 119.33 ± 4.43 103.33 ± 3.41 50.83 ± 5.10* 5.13 ± 2.54
  1. Rats were treated over a 24 h period with a single dose of either vehicle (control group), EFPA (10 mg/kg) or EFPA (10 mg/kg) + indomethacin (5 mg/kg, 1 h pretreatment) administered i.p. Data are given as means ± SEM of 6 different experiments. Statistical analyses were assessed using two-way analysis of variance (ANOVA) followed by Bonferroni’s post- test. *p < 0.05 versus control, and #p < 0.05 versus EFPA