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Table 1 Urinary excretion induced by increasing doses of EFPA in rats

From: The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

Groups Urine volume (mL/100 g) Urinary volumetric excretion (%)
2 h 4 h 6 h 8 h 2 h 4 h 6 h 8 h
Control 0.14 ± 0.09 0.20 ± 0.07 0.50 ± 0.04 0.70 ± 0.05 2.70 ± 2.83 3.80 ± 1.10 8.76 ± 0.80 13.62 ± 0.92
EFPA (5 mg/kg) 0.84 ± 0.11* 1.49 ± 0.14* 1.73 ± 0.20* 2.09 ± 0.17* 16.61 ± 2.01* 29.40 ± 3.02* 34.20 ± 3.64* 41.20 ± 3.32*
EFPA (10 mg/kg) 1.14 ± 0.13* 1.82 ± 0.11* 2.21 ± 0.15* 2.80 ± 0.20* 22.92 ± 2.60* 36.50 ± 2.53* 44.20 ± 3.80* 55.94 ± 3.40*
EFPA (20 mg/kg) 1.67 ± 0.15* 2.06 ± 0.16* 2.34 ± 0.10* 2.86 ± 0.12* 33.30 ± 4.10* 41.23 ± 2.90* 46.80 ± 2.70* 57.10 ± 1.90*
EFPA (40 mg/kg) 2.02 ± 0.11* 2.34 ± 0.10* 2.51 ± 0.18* 3.09 ± 0.13* 40.60 ± 1.70* 47.12 ± 2.83* 50.53 ± 3.80* 60.20 ± 2.90*
EFPA (80 mg/kg) 2.33 ± 0.12* 2.60 ± 0.13* 2.92 ± 0.13* 3.16 ± 0.15* 46.61 ± 2.10* 51.90 ± 2.73* 58.41 ± 1.91* 63.34 ± 3.24*
  1. The urine volumes expressed as mL/100 g were calculated based on body weight of rats and urinary volumetric excretion values are expressed as a percentage of the initial hydric overload (50 mL/kg). Data are given as means ± SEM of 6 different experiments. Statistical analyses were assessed using two-way analysis of variance (ANOVA) followed by Bonferroni’s post- test. *p ˂ 0.001 versus control