Table 1 Urinary excretion induced by increasing doses of EFPA in rats

Control

0.14 ± 0.09

0.20 ± 0.07

0.50 ± 0.04

0.70 ± 0.05

2.70 ± 2.83

3.80 ± 1.10

8.76 ± 0.80

13.62 ± 0.92

EFPA (5 mg/kg)

0.84 ± 0.11^*

1.49 ± 0.14^*

1.73 ± 0.20^*

2.09 ± 0.17^*

16.61 ± 2.01^*

29.40 ± 3.02^*

34.20 ± 3.64^*

41.20 ± 3.32^*

EFPA (10 mg/kg)

1.14 ± 0.13^*

1.82 ± 0.11^*

2.21 ± 0.15^*

2.80 ± 0.20^*

22.92 ± 2.60^*

36.50 ± 2.53^*

44.20 ± 3.80^*

55.94 ± 3.40^*

EFPA (20 mg/kg)

1.67 ± 0.15*

2.06 ± 0.16^*

2.34 ± 0.10^*

2.86 ± 0.12^*

33.30 ± 4.10^*

41.23 ± 2.90^*

46.80 ± 2.70^*

57.10 ± 1.90^*

EFPA (40 mg/kg)

2.02 ± 0.11*

2.34 ± 0.10^*

2.51 ± 0.18^*

3.09 ± 0.13^*

40.60 ± 1.70^*

47.12 ± 2.83^*

50.53 ± 3.80^*

60.20 ± 2.90^*

EFPA (80 mg/kg)

2.33 ± 0.12^*

2.60 ± 0.13^*

2.92 ± 0.13^*

3.16 ± 0.15^*

46.61 ± 2.10^*

51.90 ± 2.73^*

58.41 ± 1.91^*

63.34 ± 3.24^*